In a survey of sleeping sickness in the Ikoma-Serengeti area, carried out in October and November 1970, about 3,000 people living in the area were examined and none was found infected. Introduction Rhodesian sleeping sickness was introduced into the Musoma District mainly in the Ikoma area in the 1920's. It is believed to have been an extension of an epidemic in Maswa, Mwanza District, which li...

A search for Glossina fuscipes fuscipes puparia near homesteads in the sleeping sickness focus of Busoga revealed puparia and puparial shells under Coffea canephora (coffee), Musa sp. (banana) and Lantana camara thickets as well as under house verandahs and, once, inside a hut. This is the first description of G.f. fuscipes breeding sites in a peridomestic habitat. The implications of these fin...

Cerebrospinal fluid mononuclear cells from 40 patients with advanced Gambian sleeping sickness were examined for intracytoplasmic immunoglobulin and for B- and T-lymphocyte markers. About 5% of mononuclear cells were plasma cells. Most of the lymphocytes present were B cells. These findings suggest that the considerable lymphocytic infiltration of the nervous system seen in advanced sleeping si...

Agent-based modelling is useful for policy evaluation in fields such as epidemiology. The current paper presents a model of Human African Trypanosomiasis (HAT), or sleeping sickness: a disease which is becoming increasingly prominent due to recent epidemics. Associated medication is often scarce, whilst diagnosis through blood screening is not always effective. Current modelling methodology use...

African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue of DB829, is the second simple diamidine found to cure mice with central nervous system infections by a parenteral route of administration. 28DAP010 showed efficacy similar...

Sleeping sickness has long been a major public health problem in Uganda. From 1900 to 1920, more than 250,000 people died in an epidemic that affected the southern part of the country, particularly the Busoga region. The epidemic has traditionally been ascribed to Trypanosoma brucei gambiense, a parasite now confined to central and western Africa. The Busoga region still reports sleeping sickne...

Sleeping sickness epidemics have been noted to occur with some degree of periodicity and the question as to why this is so has been asked for quite a long time. These epidemics have been partially controlled in the past using the conventional methods of bush clearing, mass diagnostic surveys and treatment. Political, social and economic upheavals have been found to be very important factors in ...