Changes in sleep structure, and especially REM sleep, and in EEG activation were studied in relation to the cholinergic deficit found in Alzheimer's Disease (AD). With respect to sleep architecture, only REM sleep percent was reduced in AD patients compared to controls as a result of a decrease in mean REM episode duration. Different results were obtained in patients with progressive supranucle...

BACKGROUND The multi-mode modulation is a key feature of sleep EEG. And the short-term fractal property reflects the sympathovagal modulation of heart rate variability (HRV). The properties of EEG and HRV strongly correlated with sleep status and are interesting in clinic diagnosis. NEW METHOD 19 healthy female subjects were included for over-night standard polysomnographic study. Hilbert Hua...

PURPOSE Standard polysomnography (PSG) typically utilizes 4-6 channels of electroencephalography (EEG), which is inadequate to evaluate focal epileptiform activity. Though technical capability has long existed for more extensive EEG recording, few sleep laboratories have utilized this technique. The objective of this study was to determine the utility of combining PSG with 18-channel EEG in sel...

The contribution of slow brain oscillations including delta, theta, alpha, and sigma frequencies (0.5-16 Hz) to the sleep electroencephalography (EEG) is finely regulated by circadian and homeostatic influences, and reflects functional aspects of wakefulness and sleep. Accumulating evidence demonstrates that individual sleep EEG patterns in non-rapid-eye-movement (NREM) sleep and rapid-eye-move...

THIP (Gaboxadol) is a selective GABA A agonist, acting in vitro with high potency and efficacy at the extrasynaptic GABA A containing receptors. THIP was suggested to be a potential hypnotic to treat insomnia and it is currently in clinical trial. Here we assessed whether the GABA A -containing receptors mediate in vivo the effect of THIP on sleep and the sleep electroencephalogram (EEG). We...

OBJECTIVE To investigate whether sleep macrostructure and EEG power spectral density and coherence during NREM sleep are different in Asperger syndrome (AS) compared to typically developing children and adolescents. METHODS Standard all night EEG sleep parameters were obtained from 18 un-medicated subjects with AS and 14 controls (age range: 7.5-21.5years) after one adaptation night. Spectral...

Sleep electroencephalographic (EEG) slow-wave activity is increased after wakefulness and decreases during sleep. Regional sleep EEG differences are thought to be a consequence of activation of specific cortical neuronal circuits during waking. We investigated the relationship between handedness and interhemispheric brain asymmetry. Bilateral EEG recordings were obtained from the frontal and oc...

1699 EEG Activity Markers in Depression—Birchler-Pedross et al be quantified by spectral EEG correlates in the low-frequency range (1-7 Hz) during sleep and wakefulness.13-19 The intensity of low-frequency EEG activity at the beginning of sleep is proportional to the duration of prior wakefulness, and is considered to reflect the homeostatic aspect of sleep regulation.20-22 During sustained wak...

OBJECTIVE Typical changes in spectral electroencephalographic (EEG) activity and heart rate (HR) have been described in periodic leg movements (PLM) associated with or without microarousals (MA). We aimed to determine the effects of sleep stage and wakefulness on these responses to ascertain whether a common pattern of EEG and HR activation takes place. METHODS The time course of EEG spectral...

Only the recording of brain electrical activity (electroencephalogram, EEG) during sleep revealed that sleep is an active process that is tightly regulated. Thus, every night we cycle through a seemingly predefined series of discrete states (NREM and REM sleep) each with its characteristic EEG activity pattern. Sleep need is also regulated and depends to a large extent on how long we stay awake...