Background: Infection is now the most common cause of morbidity in Systemic Lupus Erythematosus (SLE). There is lack of information regarding the specific antibody forma-tion in response to vaccines in young SLE patients. Objective: To determine the efficacy of anti-tetanus antibody response in young patients with SLE. Methods: Forty SLE pa-tients with mean age of 14.1 years (range: 7-21) and 6...

Background: Systemic Lupus Eyrythematosus (SLE) is an autoimmune disease charac-terized by antibodies to nuclear antigens, particularly anti-dsDNA. Imbalance between production and destruction of immune cells causes cytopenia. Sex hormones have im-munomodulatory effects; estrogen increases the production of autoantibodies in SLE prone NZB/NZW mice. Objective: To investigate the relationship bet...

at present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsdna antibodies), erythrocyte sedimentation rate (esr), levels of c-reactive protein (crp), or cytokines such as il-2/il-2 receptor, il-6 and il-10 are used as indirect serological markers with variable degrees of significance. to date, no specific ...

systemic lupus erythematosus (sle) is an autoimmune disease in which polymorphisms within the human leukocyte antigen (hla) region have been associated to its etiology. we conducted this study to compare the hla-dqb1 allelic sequence variation among sle patients and controls in the northeast of iran. genomic dna of 40 sle patients and 83 healthy controls were amplified by polymerase chain react...

background: the aim of the present study was to determine the prevalence and prognosis of cerebrovascular accident(cva) and its subtypes among iranian patients with systemic lupus erythematosus (sle). methods: in a cross-sectional study, medical records of 575 sle patients were reviewed. the patients developing cva in their course of disease were extracted. in these patients, data about demogra...

background: recent accumulated evidence suggests that prolactin (prl) is an important immunomodulator and plays an important role in the pathogenesis of systemic lupus erythematosus (sle). the current study aimed to compare hyperprolactinemia frequency and evaluate its possible association with lupus activity in sle patients in zahedan. methods: in a case-control study we determined serum prola...

objective(s):  apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (sle), in present study we studied the apoptosis in t lymphocytes from iranian sle patientsat protein and gene expression levels for some molecules which are involved in apopt...

normal 0 false false false en-us x-none ar-sa background: neuropsychiatric abnormalities are among the most common manifestations of systemic lupus erythematosus (sle). they have been proposed to be associated with impaired cerebral blood flow (cbf). cerebral vasomotor reactivity (vmr) is a hemodynamic parameter effective in the autoregulation of cbf. the aim of the present study is to determin...

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. Objective: To investigate humoral immunity and specific-antibody formation in response to a...