نتایج جستجو برای: slc19a1
تعداد نتایج: 126 فیلتر نتایج به سال:
Urinary bladder cancer (UBC) ranks ninth in worldwide cancer. In Egypt, the pattern of bladder cancer is unique in that both the transitional and squamous cell types prevail. Despite much research on the topic, it is still difficult to predict tumor progression, optimal therapy and clinical outcome. The reduced folate carrier (RFC/SLC19A1) is the major transport system for folates in mammalian ...
BACKGROUND Recurrence and toxicity occur commonly among patients with rectal cancer who are treated with 5-fluorouracil (5-FU). The authors hypothesized that genetic variation in folate-metabolizing genes could play a role in interindividual variability. The objective of the current study was to evaluate the associations between genetic variants in folate-metabolizing genes and clinical outcome...
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on serum folate and plasma methylmalonic acid (MMA, an indicator of vitamin B<formu...
on the use of formamide and reduced incubation temperatures. Here we describe a modification of FoLT PCR which allows direct amplification from solid tissue samples without the need for any DNA purification steps. Two oligonucleotide primer combinations directed against the murine I82 microglobulin gene were used in this study. Using a standard PCR protocol it was not possible to amplify the ap...
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