For skin contact medical devices, realizing a strong with is essential to precisely detect human biological information and enable human-machine interaction. In this study, we aimed fabricate characterize an inclusion complex film (ICF) for adhesion using α-cyclodextrin (α-CD) nonanyl group-modified PVA (C9-PVA) under wet conditions. Based on the water insolubility of C9-PVA ability α-CD alkyl ...

Yucatan hairless micropig (YHMP) skin has been shown to have histology and physiologic properties similar to human skin. To assess the relationship between the permeability of corticosteroid ointments and five types of commonly used admixtures of corticosteroid through hairless mice (HM) or YHMP skin and the clinical effects in humans, we conduct by in vitro experiments using HM and YHMP skin. ...

decline curve analysis has some advantages over transient well test analysis in which it is not required to shut-in the well and also wellbore storage effects do not exist. few studies have been done on decline curve analysis of naturally fractured reservoirs but there are even some limitations with available models. on the other hand well test could be expensive and in some operational conditi...

MISTRETTA, CHARLOTTE M. Permeability of tongue epithelium and its relation to taste. Am. J. Physiol. 220(5) : 1162-l 167. 197 1 .-The permeability of rat tongue epithelium was investigated to provide information on the accessibility of free lingual nerve endings to chemical stimuli. Permeability of rat belly skin was also studied. Dorsal tongue epithelium was removed after subepithelial injecti...

The problem of predicting the rate of percutaneous absorption of a drug is an important issue, particular with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain is that human skin permeability to penetrants (often characterised by Kp, the permeability coefficient) has been shown to be inherently non-linear when mathemat...

Objective (s): Transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. A novel testosterone transdermal delivery system (TDDS) was developed using a palm oil base called HAMINTM (a commercial product) and tested using in vitro and in vi...

Purification of the vascular permeability factor of Pseudomonas aeruginosa resulted in loss of activity and qualitative changes in skin lesions in rabbits. Addition to the purified vascular permeability factor of a macromolecular fraction with no vascular permeability factor activity restored the original characteristics of the skin reaction.

Microneedles array is a new transdermal drug delivery technique designed to create holes in 15 the epidermis and penetrate the stratum corneum, thus avoiding the high resistance of this barrier. Microneedles have been shown to increase the skin permeability of drugs with no or little pain. However, the skin permeability of epidermis while using microneedle arrays has yet to be fully studied. In...