The dysregulation of apoptosis occurs in many cutaneous disease states. Several apoptosis inhibitors have been shown elevated in neoplasms and in some inflammatory conditions, but their relation to proliferative and apoptotic states has not been defined. We examined the expression of the apoptosis inhibitor survivin in a panel of keratinocytic neoplasms and hyperproliferative skin lesions using...

This chapter reviews the clinical presentation, histopathology, immunoprofile and molecular features of Langerhans cell neoplasms of the skin including Langerhans cell histiocytosis (LCH) and its malignant counterpart, Langerhans cell sarcoma (LCS). Biopsy of the skin is a useful method to confirm LCH/LCS diagnosis, as cutaneous involvement is seen in more than 50% cases. Skin can be the only p...

BACKGROUND: Deevelopment of new diagnostics and treatment malignant neoplasms methods increase their efficiency, safety is one the most urgent tasks modern oncology. Currently, targeted immunotherapy contributes to neoplasms. One examples skin melanoma.
 AIMS: This study aimed investigate influence therapeutic tactics on epidemiological indicators in morbidity MATERIALS AND METHODS: The us...

Squamous cell carcinoma (SCC) and keratoacanthoma (KA) are skin neoplasms of epithelial origin. In contrast to clearly malignant skin neoplasm SCC, KA is an unusual cutaneous neoplasm with a tendency to regression. The distinction between these two neoplasms, on histological grounds only, is still a challenge. In order to investigate further and to assess the possible differences in transformin...

Purpose: to assess the effectiveness of carbon dioxide laser light in treatment benign skin neoplasms. Material and methods. The researchers have analyzed outcomes 1394 patients treated for In main group (n = 1184), photocoagulation (vaporization) photohydraulic preparation were applied. Laser surgical devices “Lancet-1” “Lancet-2” continuous pulsed modes, power up 20 W, focused beam 1 mm used....

OBJECTIVE To study the occurrence and types of neoplasms developed by patients who underwent an orthotopic cardiac transplantation under the Program of Cardiac Transplantation of Escola Paulista de Medicina, Federal University of São Paulo. METHODS This is an observational study of 106 patients who underwent orthotopic cardiac transplantation from November 1986 to September 2002 and survived ...