Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or destruction/loss melanin. Skin cells (melanocytes) are responsible for producing melanin, substance that gives pigmentation to skin. This review aims provide a comprehensive overview current state knowledge about vitiligo. Although there no specific ethnic group, gender, skin type more prone vitiligo ...

BACKGROUND Understanding the physiological, chemical, and biophysical characteristics of the skin helps us to arrange a proper approach to the management of skin diseases. OBJECTIVE The aim of this study was to measure 6 biophysical characteristics of normal skin (sebum content, hydration, transepidermal water loss (TEWL), erythema index, melanin index, and elasticity) in a normal population ...

Effects of histamine per se along with its specific agonists and antagonists were studied on the skin melanophores of Hemidactylus flaviviridis to study the role of histamine receptors in pigmentation. Histamine and 2-methyl histamine induced powerful melanin aggregation effects, leading to paling of the skin through stimulation of H1 receptors. On the other hand, 4-methyl histamine, a specific...

BACKGROUND Evolutionary psychology suggests that skin signals aspects of mate value, yet only limited empirical evidence exists for this assertion. OBJECTIVES We sought to study the relationship between perception of skin condition and homogeneity of color/chromophore distribution. METHODS Cropped skin cheek images from 170 girls and women (11-76 years) were blind-rated for attractiveness, ...

The links between appearance and health influence human social interactions and are medically important, yet the facial cues influencing health judgments are unclear, and few studies describe connections to actual health. Increased facial skin yellowness (CIELab b*) and lightness (L*) appear healthy in Caucasian faces, but it is unclear why. Skin yellowness is primarily affected by melanin and ...

Human melanocytes from individuals with different skin types, as well as from the skin of the same individual, are heterogeneous in their melanin content. This heterogeneity may be attributed to differences in the activity and expression of the three melanogenic proteins: tyrosinase and tyrosinase-related proteins 1 and 2 (gp75 and DOPAchrome tautomerase, respectively), which in turn are affect...

©2002, IS&T—The Society for Imaging Science and Technology outer thin layer, epidermis, and an inner, relatively thick layer, dermis. For normal human skin, the absorption of the epidermis is dominated by a black pigment called melanin, though there are five different pigments in the skin.6 The spectral characteristics of different races or different individuals are due only to variation in the...

The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer. Colored mouse strains, C57BL/6NCr, BDF1, and C3H/He, have clear EPR sign...

Melanin is one of the most important factors affecting skin color. Melanogenesis is the bioprocess of melanin production by melanocytes in the skin and hair follicles and is mediated by several enzymes, such as tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2. Convenient enzymatic transformation of the simple phenol pyrogallol with polyphenol oxidase originating from pear to an oxidati...

nepeta satureioides boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. the aim of this study was to evaluate the effect of methanol (meoh), n -hexane and dichloromethane (ch 2 cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in b16f10 melanoma cell line. the b16f10 cell line viability after treatment with increa...