The gold standard surgical treatment of chronic anal fissure is lateral internal sphincterotomy which lowers the resting anal pressure and effectively heals the majority of fissures. Local application of 0.2% glyceryl trinitrate ointment has been used as an agent for chemical sphincterotomy, causing temporary alleviation of sphincter spasm and allowing the fissure to heal without compromising t...

Background: For the prevention of dental caries, fissure sealants application is recommended if pits and fissures are very deep and narrow, creating a physical barrier for the plaque's accumulation, in these specific anatomical areas of the tooth. Aim: This review article about fissure sealant aims to address the main properties, indications, advantages and limitations of fissure sealants that ...

Anal fissure is one of the most common causes of severe anal pain. Factors which predispose people to develop anal fissure include diarrhea, constipation, childbirth, medication as well as constant saddle vibration (amongst professional mountain-bikers) and using a jet of water from a bidet-toilet. For many years, it has been generally accepted that a sphincterotomy, whether surgical or pharmac...

Anal fissure is an ischemic ulcer that occurs in anoderm and it has no obvious etiology and pathophysiology in current medicine. Anal fissure has a profound history in Persian and Persian medicine and wallflower (Erysimum cheiri (L.) Crantz) has been a common medication in this case. Traditional oil and/or dilute decoction of wallflower has been introduced as an effective topical medic...

Harlequin ichthyosis (HI), which is the most severe genodermatosis, is caused by loss-of-function mutations in ABCA12, a member of the ATP-binding cassette transporter family. To investigate the pathomechanism of HI and the function of the ABCA12 protein, we generated ABCA12-deficient mice (Abca12(-/-)) by targeting Abca12. Abca12(-/-) mice closely reproduce the human HI phenotype, showing mark...

Anal fissure in childhood usually heals quickly after treatment with stool softeners and a local anaesthetic ointment; infection does not usually occur. Two cases are reported in which Lancefield group A , haemolytic streptococci were isolated from cultures from the perianal skin, which was erythematous and excoriated. streptocci were grown from culture of a perianal swab. She was asymptomatic ...

statement of problem: pit and fissure sealant therapy has been approved as an effective measure in the prevention of occlusal dental caries. resin based ma- terials are the most common materials used worldwide. a variety of resin based fissure sealants are produced and used. most of them have been presented with ideal results in research environment. however, their effectiveness in the real lif...

The aim of this study was to develop a preparation of a hydroalcoholic extract of Quercus infectoria in order to study the physicochemical parameters, and to identify and quantitatively determine the amount of Polyphenols and Tannin in the galls and in the extract. Preparation of an extract rich in Tannin from the galls of Quercus infectoria, as an astringent, can make incorporation into recta...

Introduction. Sphincterotomy is a pathogenetically justified method of surgical treatment chronic anal fissures with spasm the sphincter, but risk incontinence can reach 44%. Therefore, other methods are being sought to eliminate and greatest interest medical relaxation internal sphincter. Aim. To determine efficacy limitations use combined preparation in form gel 0.3% nifedipine 2.0% lidocaine...

OBJECTIVE To study the association between analfissures and cow's milk allergy (CMA) in infants. METHODS AND METHOD: In a prospective study, 72 confirmed cases of CMA in infants were examined for anal fissure by pediatricians with five years' experience. A positive finding was defined as when an anal fissure was detected by at least two out of three examiners. RESULTS Of infants with CMA with...