Chronic non-infectious diseases are the leading cause of premature death according to WHO data. This review considers evolution studying and modern views domestic foreign authors on role skeletal muscles in maintaining health preventing chronic diseases. An idea regarding nervous reflex influence from working both individual organs body as a whole is presented. The myokines, specific proteins p...

Rare skeletal diseases are a diverse group of diseases that primarily affect development of the skeleton. There are more than 450 unique phenotypes that, although individually rare, have an overall prevalence of at least 1 per 4,000 children. Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are skeletal diseases caused by missense mutations/deletions in the genes encoding im...

Congenital skeletal anomalies are rare disorders, with a subset affecting both the cranial and appendicular skeleton. Two categories, craniosynostosis syndromes and chondrodysplasias, frequently result from aberrant regulation of the fibroblast growth factor (FGF) signaling pathway. Our recent work has implicated FGF signaling in a third category: ciliopathic skeletal dysplasias. In this work, ...

PURPOSE OF REVIEW There is an increased risk of osteoporotic fractures and osteonecrosis often at a young age among patients with certain systemic autoimmune diseases. The loss of bone mineral density and bone integrity seen with these diseases often cannot be explained by traditional risk factors alone. In this review, we focus on rheumatoid arthritis and systemic lupus erythematosus, two syst...

High-resolution bone imaging has made tremendous progress in the recent past. Both imaging modalities, computed tomography as well as MR imaging, have improved image quality. New developments such as HR-pQCT now make it possible to acquire in vivo images at peripheral sites with isotropic voxel size in a very short time. Further enhancements in the MR field have made it possible to image more c...

Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibi...

noncompaction of the ventricular myocardium is an embryonic cardiomyopathy that is increasingly being recognized. noncompaction of lv myocardium, right ventricular myocardium, or both can occur in isolation, in congenital heart diseases, in valvular heart diseases, in neuromuscular disorders, skeletal abnormalities and in endocrinologic abnormalities. clinical manifestations of ventricular non-...

Skeletal muscle is a vital tissue not only for maintaining posture and body movements but also energy metabolism in human body. highly plastic response to various stimuli, resistance exercise or anabolic hormones can increase mass, which termed “muscle hypertrophy”. Contrary, immobility, aging severe illness reduce atrophy”. Loss of skeletal mass associated with loss independent living, the mor...

In 2019, the Nosology Committee of International Skeletal Dysplasia Society provided an updated version and Classification Genetic Disorders. This is a reference list recognized diseases in humans their causal genes published to help clinician diagnosis scientific research advances. Complementary mammalian models, zebrafish has emerged as interesting species evaluate chemical treatments against...

An article reviews occurence, mechanism and treatment of drug induced reactions that resemble certain idiopathic rheumatic diseases syndromes or are indistinguishable from them, is, drug-induced lupus erythematosus, hyperuricemia gout, osteopathy, statin-induced skeletal muscle damage, fluoroquinolone-induced tendinopathy, autoimmune inflammatory by checkpoint inhibitors.