BACKGROUND Oral itraconazole is an antifungal that has been shown to be of benefit to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may similarly benefit patients with allergic fungal sinusitis (AFS), a disease similar to ABPA. This study was designed to evaluate the therapeutic response of itraconazole in patients with refractory chronic funga...

Allergic fungal sinusitis (AFS) is a rare disease of naso-sinusal complex affecting mainly young, immunocompetent adults who complain of chronic rhinitis and/or recurrent nasal polyposis despite medical and/or surgical treatment. Aim of the study is to analyse, from an allergological and otorhinolaryngological point of view, patients affected by the so-called "allergic fungal sinusitis" in orde...

Invasive sinus Aspergillus infection has been reported in the last decade with increased frequency, most commonly in the setting of hematologic malignancy, neutropenia, HIV infection and other states of immunosuppression. Fungal rhinosinusitis can be broadly classified into two varieties—invasive and noninvasive on the basis of tissue invasion. Invasive fungal sinusitis are acute invasive, chro...

Clinical and microbiologic aspects of fungal sinusitis occurring in six patients are presented. Three of the six patients were immunosuppressed. Fatal disseminated fungal disease developed in two of those immunosuppressed. The three patients with normal immune function had fungal infections confined to the nasal sinuses. Aspergillus fumigatus and Aspergillus flavus were recovered from the immun...

Allergic fungal sinusitis (AFS) is a non-invasive form of allergic sinusitis, resulting from the IgE-mediated hypersensitivity reaction to fungal antigen in atopic individuals. It was first described in 1983 by Katzenstein.1 It usually follows a slow, non-aggressive course, and a wide variety of fungal agents have been implicated, with the vast majority belonging to the Dematiaceae family, such...

Background: Fungal sinusitis of isolated sphenoid sinus is a rare entity. Most of the sufferers referred with complications since the primary manifestations are non-characteristic. Case presentation: We describe a 40-year old woman presenting with severe headache, diplopia, and limited right-eye movement. Further studies proposed isolated sphenoidal sinusitis, for which she underwent endoscopic...

Neurosurgical Management of Bipolaris-Specific Skull Base Allergic Fungal Sinusitis: Diagnostic Criteria and Outcome O the past decade, the incidence of fungal infections has increased dramatically. Fungal paranasal sinus disease, a large component of fungal infections, is common and is defined by the host and the host’s response to the fungus. Invasive fungal sinusitis occurs in immunocompromi...