The binding of thyroxine by bovine and human serum albumin has been studied by measurements of the quenching of the ultraviolet fluorescence of the protein. The results obtained by this method have been compared with those of equilibrium dialysis measurements. Both approaches agree in assigning to serum albumin a single binding site of high affinity and three or more weak sites. The binding con...

This study evaluated the single-pass system for the short-term dialysis treatment of dogs and cats with experimental renal failure. The hemodialyzer was equipped with a thin and highly permeable Cuprophan membrane. Four animals (two dogs and two cats) with total uretic obstruction were dialyzed twice in a one-week period. The vascular access by venipuncture of external jugular vein delivered mo...

This study evaluated the single-pass system for the short-term dialysis treatment of dogs and cats with experimental renal failure. The hemodialyzer was equipped with a thin and highly permeable Cuprophan membrane. Four animals (two dogs and two cats) with total uretic obstruction were dialyzed twice in a one-week period. The vascular access by venipuncture of external jugular vein delivered mo...

Dialysis and adsorption processes are commonly implemented in liver support devices for the removal of albumin-bound toxins such as tryptophan. In this work, dialysis and adsorption of tryptophan from albumin-containing solutions were investigated; in particular, the effect of albumin concentration on both processes was analysed. Theoretical models accounting for albumin-tryptophan binding were...

BACKGROUND The mortality rate in patients with severe liver dysfunction secondary to alcoholic liver disease (ALD) who do not respond to the standard treatment is exceptionally high. OBJECTIVES The main aim of this study was to evaluate the usefulness of applying extracorporeal liver support techniques to treat this group of patients. PATIENTS AND METHODS The data from 23 hospital admission...

BACKGROUND Carbamylation is an irreversible process of non-enzymatic modification of proteins by the breakdown products of urea. For haemoglobin (Hb), the extent of carbamylation is a marker of urea exposure and has been proposed as an indicator of the control of uraemia by dialysis, analogous to the use of Hb glycosylation in diabetic patients. METHODS We performed a cross-sectional study of...

Introduction. Accumulation of middle molecular weight uremic toxins causes various complications in chronic hemodialysis (HD) patients. Postdilution online hemodiafiltration (OL-HDF) efficiently removes these molecules. This study aimed to assess the effectiveness three different dialysis membranes removing ?2- microglobulin (?2m) within a single session postdilution OL-HDF. Method. A prospecti...

Dialysis adequacy has a major impact on the outcome of continuous ambulatory peritoneal dialysis (CAPD) patients. However, most studies on peritoneal dialysis adequacy have focused on patients with significant residual renal function. The present study examined the effect of dialysis adequacy on anuric CAPD patients. A single-center prospective observational study on 140 anuric CAPD patients wa...

Whether acute or chronic, liver failure is a state of dysfunction that can progress to multiorgan failure. Mortality in patients approximately 80–90% and caused by detoxification failure, which triggers other immediate complications, such as encephalopathy, coagulopathy, jaundice, cholestasis, kidney The ideal treatment for transplantation, but the long waiting period right donor match causes u...