MicroRNAs (miRNAs) are known as a new class of small RNAs (18-25 nucleotides) that regulate gene expression at multiple levels from transcription to translation. Considering the important role of miRNAs in cell proliferation, differentiation, and apoptosis, any variations in their expression can contribute to various anomalies, such as tumorigenesis. Single-nucleotide polymorphisms (SNPs) have ...

A set of single nucleotide polymorphisms (SNP) was developed from the transcriptome gorgonian Leptogorgia sarmentosa. 21,491 putative SNPs were identified, and a selected 320 tested using MassARRAY System on 95 samples NW Mediterranean. total 153 successfully genotyped found to be polymorphic. The newly loci will valuable tool for population genetics studies one most ubiquitous species in Medit...

Introduction: Graves Disease (GD) is the most common cause of primary hyperthyroidism. It an autoimmune disorder characterized by presence thyrotropin related antibodies that stimulate thyroidal cells, resulting in overproduction thyroid hormones. has been reported cytokines might be involved GD pathogenesis. So, aim present study was to investigate possible associations between IL-37 Single Nu...

background: coronary artery disease (cad) is a multifactorial and heterogenic disease. recently, genome-wide association studies have reported that rs1333040 (c/t) and rs1004638 (a/t) single nucleotide polymorphisms (snps) in the 9p21 locus have very strong association with cad. this study aimed to examine these associations in southwest of iran. methods: blood samples were collected from 200 c...

Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...

UNLABELLED SNPNB is a user-friendly and platform-independent application for analyzing Single Nucleotide Polymorphism NeighBoring sequence context and nucleotide bias patterns, and subsequently evaluating the effective SNP size for the bias patterns observed from the whole data. It was implemented by Java and Perl. SNPNB can efficiently handle genome-wide or chromosome-wide SNP data analysis in...

Tomato Fusarium wilt caused by oxysporum f.sp. lycopersici (Fol) constrains tomato production worldwide. Three hundred forty accessions were evaluated for resistance and single nucleotide polymorphisms (SNPs) associated with resistance. The disease evaluation revealed that 15, 13, 15 identified as resistant in Test 1, 2, Mean data, respectively, the severity index (DSI) ranging from 0-16.7%. A ...

introduction: hepatitis b is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (hcc). interleukin-12 (il12) is responsible for activation of th1 immune responses, leading to possible clearance of hbv infection from the host’s body. the host’s immune-genetic background plays an important role in t...

conventional methods for fungal identification in the clinical laboratory rely on morphological andphysiological tests. these tests often need several days or weeks to complete and are frequentlyunspecific. molecular identification mostly implies sequencing, which is relatively expensive andtime-consuming, as well as impractical for large numbers of isolates. the rolling circleamplification app...

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