OBJECTIVE To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN Prospective study. SETTING University hospital. METHODS 75 patients underwent simultaneo...

Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross-contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with technetium-9...

UNLABELLED A triple-detector, multipinhole SPECT system was optimally configured to perform simultaneous (201)Tl (stress)/(99m)Tc (rest) myocardial perfusion imaging (MPI) using a protocol that permitted direct diagnostic comparison of this multipinhole SPECT system with conventional rotational SPECT. METHODS Both the rotational and the multipinhole SPECT systems used the same model gamma-det...

UNLABELLED We are combining nuclear medicine with molecular biology to establish a sensitive, quantitative, and tomographic method with which to detect gene expression in pancreatic islet cells in vivo. Dual-isotope SPECT can be used to image multiple molecular events simultaneously, and coregistration of SPECT and CT images enables visualization of reporter gene expression in the correct anato...

UNLABELLED Ventilation-perfusion (V/Q) SPECT has been reported to improve the diagnostic performance of V/Q imaging for the diagnosis of pulmonary embolism (PE). However, only sparse data based on an objective reference test are available, and the criteria used for interpretation have varied widely. Therefore, the aim of our study was to assess the performance of V/Q SPECT using various criteri...

OBJECTIVE To determine whether, compared with fundamental imaging, second harmonic imaging can improve the accuracy of dobutamine stress echocardiography for identifying viable myocardium, using nuclear imaging as a reference. PATIENTS 30 patients with chronic left ventricular dysfunction (mean (SD) age, 60 (8) years; 22 men). METHODS Dobutamine stress echocardiography was carried out in al...

It is likely that clinical applications of ECG-gated single-photon emission computed tomography (SPECT) are established in nuclear cardiology practice because of the improved diagnostic accuracy of gated SPECT imaging for the detection of coronary artery disease and because this technique enables not only simultaneous assessment of myocardial perfusion and function but also improvement of risk ...

In the rapidly changing world of medicine, boundaries between specialties are constantly being challenged. Fused and hybrid imaging with integration of single photon emission computed tomography (SPECT) and computed tomography (CT)(SPECT/ CT) and positron emission tomography (PET) and CT (PET/CT), represent an area of very rapid growth with significant implications for the medical profession. S...

A technique is described involving simultaneous, dual-isotope SPECT imaging. Using 123I and 201TI, a patient study is presented, demonstrating the clinical utility of this technique in the detection and characterization of parathyroid pathology. The use of this technique in other clinical situations is discussed.