Milk Thistle, Silybum marianum Gaertn. plant has been used for centuries as a natural remedy for several diseases. Its active constituent, silymarin displays several medicinal properties, viz. antioxidant, hepatoprotective, cytoprotective, amelioration of hepatic collagen accumulation in advanced fibrosis, immunomodulatory activity, etc. Present paper summarizes various research reports on the ...

Silymarin and its flavonolignan isomers, silybin, isosilybin, dehydrosilybin, silychristin, silydianin, and a few flavonoids mainly taxifolin, have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for silymarin and active seed extracts of Silybum marianum against different bacteria, fungi, viruses and pa...

belonging to the family Compositae which comprises about 1000 genera and 20000 species. S. marianum is common in Kashmir at an altitude of 1800—4000 m and is cultivated for ornaments in gardens. The plant is used in the treatment of hepatitis, cirrhosis, regeneration from liver diseases, and liver poisoning. A decoction of this plant is also used by the local physicians for the treatment of a v...

Introduction: This review focuses on the efficacy and safety of Iranian medicinal plants found effective in the management of diabetes in humans and animals. Material and methods: EMBASE, Scopus, PubMed, Web of Science, Google Scholar, and IranMedex databases were searched up to 8 October 2007. The search terms were “diabetes” and “plant”, “herb”, “traditional”, and “natural” or “herbal medicin...

Silybin A (1), silybin B (2), and isosilybin A (3), three of the seven flavonolignans that constitute silymarin, an extract of the fruits of milk thistle (Silybum marianum), were detected for the first time from a fungal endophyte, Aspergillus iizukae, isolated from the surface-sterilized leaves of S. marianum. The flavonolignans were identified using a UPLC-PDA-HRMS-MS/MS method by matching re...