OBJECTIVES To compare the in vitro scleral permeability of carboplatin using either a fibrin sealant or a balanced salt solution (BSS) vehicle and to measure in vivo ocular tissue levels following subconjunctival injection of carboplatin in fibrin sealant or BSS. METHODS The permeability of carboplatin in fibrin sealant or BSS through human eye bank sclera was tested using an in vitro perfusi...

BACKGROUND Fibrin sealant is an effective hemostatic agent and a useful tissue sealant. Studies have also suggested that fibrin sealant may accelerate the normal wound-healing process. OBJECTIVE This study was designed to ascertain whether fibrin sealant would enhance wound healing after CO(2) laser resurfacing in a guinea pig model. METHODS The CO(2) laser was used to create equal areas of...

OBJECTIVE To introduce and assess a system for the delivery of fibroblast growth factor to autologous cartilage grafts using fibrin sealant and analyze whether this "enhancement" results in reduced rates of cartilage resorption and greater preservation of normal architectural features compared with "unenhanced" cartilage grafts. METHODS Auricular cartilage segments measuring 1 cm(2) were harv...

BACKGROUND The most common complication of latissimus dorsi myocutaneous flap in breast reconstruction is seroma formation in the back. Many clinical studies have shown that fibrin sealant reduces seroma formation. We investigated any statistically significant differences in postoperative drainage and seroma formation when utilizing the fibrin sealant on the site of the latissimus dorsi myocuta...

Address for Correspondence: Dr.Venkatesh G Kamath, MBBS, MD Anatomy, Assistant Professor, Yenepoya Medical College, Deralakatte, Mangalore, India. E-Mail: [email protected] Access this Article online Quick Response code Web site: *1&2 Assistant Professor, 3 Lecturer, 4 Professor & HOD. Department of Anatomy, Yenepoya Medical College, Deralakatte, Mangalore, India. Background: The trac...

Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. Th...

BACKGROUND This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICEL(™) Fibrin Sealant (Human)) during vascular surgery. METHODS This prospective randomized controlled trial compared the haemostatic effectiveness of fibrin sealant (75 patients) or manual compression (72) in polytetrafluoroethylene (PTFE) arterial anastomoses. The primary endpoint was the absenc...

Introduction: Due to concerns about histological caries and recurrent caries after the use of sealants, adhesive systems containing fluoride and antibacterial agents have been proposed. The aim of this study was to evaluate the microleakage of sealants after the use of antibacterial chlorhexidine solution on etched enamel with and without the use of fifth- and sixth-generation adhesive systems....

The objective of this GLP study was to evaluate the safety and effectiveness of Adherus Dural Sealant and Adherus Spinal Sealant when used to achieve watertight dural closure in a canine lumbar durotomy repair model. Another important objective of this study was to determine whether Adherus Dural and Adherus Spinal Sealants would inhibit the formation of peridural fibrosis and dural adhesions a...

Community service-learning (CSL) in predoctoral dental education might be an effective tool for increasing sealant use by dentists--thus benefitting underserved children while facilitating students' learning of a clinical procedure in a real-life setting. This study reviewed the scientific literature on this topic in order to 1) evaluate the reasons for low sealant use among dentists, 2) consid...