Calorie restriction through ingesting no or minimal amounts of food and caloric beverages for periods of time is called fasting. Fasting can affect body through changing in physical and metabolic adaptations, as well as mineral and hormonal status. However, psychological effects and sometimes medical complications are likely in case of inappropriate fasting. Fasting is associated with changes i...

Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

objective(s): the study aimed to investigate the effects of resveratrol on colorectal cancer hct116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. materials and methods: we chose the appropriate time and concentration of recombinant human sonic hedgehog (shh) stimulation by cell viability. the proportion of cel...

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...

calorie restriction through ingesting no or minimal amounts of food and caloric beverages for periods of time is called fasting. fasting can affect body through changing in physical and metabolic adaptations, as well as mineral and hormonal status. however, psychological effects and sometimes medical complications are likely in case of inappropriate fasting. fasting is associated with changes i...

Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods: We chose the appropriate time and concentration of recombinant human Sonic hedgehog (Shh) stimulation by cell viability. The proportion of cel...

Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...

salinization of crop lands is one of the most important reasons for reduction in productivity and threats food security. activation of signaling process in plants is the first step during sense environmental cues and stress signals. identification of the components of plant intracellular signaling mechanisms, pathways, and networks in response to salt stress in aegilops tauschii (the d genome d...

Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these ...