نتایج جستجو برای: signal regulatory proteins sirp
تعداد نتایج: 1068020 فیلتر نتایج به سال:
CD47 on red blood cells (RBCs) reportedly signals “self” by binding SIRP on phagocytes, at least in mice. Such interactions across and within species, from mouse to human, are not yet clear and neither is the relation to cell adhesion. Using human SIRP 1 as a probe, antibody-inhibitable binding to CD47 was found only with human and pig RBCs (not mouse, rat, or cow). In addition, CD47mediated ad...
the biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. so far, many computational and statistical methods such as pca and ica have been employed for computing low-dimensional or hidden representat...
Comparison of transcriptomic and proteomic data from pathologically similar multiple sclerosis (MS) lesions reveals down-regulation of CD47 at the messenger RNA level and low abundance at the protein level. Immunohistochemical studies demonstrate that CD47 is expressed in normal myelin and in foamy macrophages and reactive astrocytes within active MS lesions. We demonstrate that CD47(-/-) mice ...
Recent advances with immunotherapy agents for the treatment of cancer have provided remarkable, and in some cases, curative results. Our laboratory has identified CD47 as an important "don't eat me" signal expressed on malignant cells. Blockade of the CD47:SIRP-α axis between tumor cells and innate immune cells (monocytes, macrophages, and dendritic cells) increases tumor cell phagocytosis in b...
Receptor biologists have traditionally focused on receptors that are physiologically coupled to inductive responses such as gene expression, cytokinesis, secretion, or entry into the cell cycle. It has generally been assumed that such inductive responses were terminated by ligand decay or receptor desensitization, which lead to cessation of signaling. While such mechanisms are clearly operative...
CD47 on erythrocytes inhibits phagocytosis through interaction with the inhibitory immunoreceptor SIRP expressed by macrophages. Thus, the CD47-SIRP interaction constitutes a negative signal for erythrocyte phagocytosis. However, we report here that CD47 does not only function as a “do not eat me” signal for uptake but can also act as an “eat me” signal. In particular, a subset of old erythrocy...
backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...
Macrophages are vital to innate immunity, and express pattern recognition receptors and http://www.jbc.org/cgi/doi/10.1074/jbc.M114.614057 The latest version is at JBC Papers in Press. Published on December 23, 2014 as Manuscript M114.614057 Copyright 2014 by The American Society for Biochemistry and Molecular Biology, Inc. by gest on O cber 5, 2017 hp://w w w .jb.org/ D ow nladed from Function...
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