70 family of sigma factors. Regulation of gene expression is an essential mechanism that allows bacteria to rapidly adapt to alterations in their environment. In this way, they preserve energy and profit by expressing particular genes only when required. Gene expression in bacteria is regulated primarily at the level of transcription initiation by modulating promoter recognition of the RNA poly...

14-3-3 sigma is induced by tumor suppressor protein p53 in response to DNA damage. p53 can directly transactivate the expression of 14-3-3 sigma to cause a G(2) cell cycle arrest when cell DNA is damaged. The expression of 14-3-3 sigma protein is down-regulated in various tumors, but its function has not been fully established. Protein kinase B/Akt, a crucial regulator of oncogenic signal invol...

Let $S(G^{sigma})$ be the skew-adjacency matrix of the oriented graph $G^{sigma}$, which is obtained from a simple undirected graph $G$ by assigning an orientation $sigma$ to each of its edges. The skew energy of an oriented graph $G^{sigma}$ is defined as the sum of absolute values of all eigenvalues of $S(G^{sigma})$. Two oriented graphs are said to be skew equienergetic iftheir skew energies...

Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation. As the regulon of a single sigma factor can be composed of hundreds of genes, sigma factors can provide effective mechanisms for simultaneously regulating expression of large numbers of prokaryotic ...

In Bacillus subtilis, the DNA binding protein Spo0A activates transcription from two classes of promoters, those used by RNA polymerase containing the primary sigma factor, sigma(A) (e.g., spoIIG), and those used by RNA polymerase containing the secondary sigma factor, sigma(H) (e.g., spoIIA). Several single amino acid substitutions in region 4 of sigma(A) define positions in sigma(A) that are ...

Let $mathcal{A}$ be a Banach algebra and $mathcal{M}$ be a Banach $mathcal{A}$-bimodule. We say that a linear mapping $delta:mathcal{A} rightarrow mathcal{M}$ is a generalized $sigma$-derivation whenever there exists a $sigma$-derivation $d:mathcal{A} rightarrow mathcal{M}$ such that $delta(ab) = delta(a)sigma(b) + sigma(a)d(b)$, for all $a,b in mathcal{A}$. Giving some facts concerning general...

Anti-sigma factors regulate prokaryotic gene expression through interactions with specific sigma factors. The bacteriophage T4 anti-sigma factor AsiA is a molecular switch that both inhibits transcription from bacterial promoters and phage early promoters and promotes transcription at phage middle promoters through its interaction with the primary sigma factor of Escherichia coli, sigma(70). As...

bldN is one of a set of genes required for the formation of specialized, spore-bearing aerial hyphae during differentiation in the mycelial bacterium Streptomyces coelicolor. Previous analysis (M. J. Bibb et al., J. Bacteriol. 182:4606-4616, 2000) showed that bldN encodes a member of the extracytoplasmic function subfamily of RNA polymerase sigma factors and that translation from the most stron...