17. Wolman, L., and Hardy, A. G. : Spinal cord infarction associated with sickle trait. Paraplegia, 7:282, 1970. 18. Schenk, E. A. : Sickle cell trait and superior longitudinal sinus thrombosis. Ann. Intern. Med., 60:282, 1970. 19. Jones, S. R., Binder, R. A., and Donowho, E. M. : Sudden death in sickle cell trait. New Eng. J. Med., 282:323, 1970. 20. Song, J. : Pathology of sickle cell disease...

Sickle cell disease (SCD) is one of the most common inherited disorders of haemoglobin in Africa and it is expected that sickle cell trait varies in frequency in different areas in Sudan. An extensive literature search was carried out accessing the US National Library of Medicine, the WHO Eastern Mediterranean Region resources, the Catalogue for Transmission Genetics in Arabs and papers and doc...

Aims: To assess the accuracy and precision of measuring haemoglobin A2 by high performance liquid chromatography (HPLC) in the presence and absence of sickle cell trait, with or without a thalassaemia trait. Methods: The haemoglobin A2 percentage and the haemoglobin A2 plus S percentages were determined by HPLC on 82 normal controls and 78 patients with sickle cell trait, respectively; the a th...

In regions highly endemic for Plasmodium falciparum malaria, red cell polymorphisms that confer resistance to severe disease are widespread. Sickle cell trait, alpha-thalassemia, glucose-6-phosphate dehydrogenase deficiency, and blood groups were determined in 100 children from Gabon with severe malaria who were matched with 100 children with mild malaria and followed up for evaluation of reinf...

Background: Approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. This study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia. Methods: Fifteen compound heterozygous sickle cell thalassemia (SCT) and 23 β-thalassemia trait patients were st...

1. Duvic C, Bordier L, Hertig A, Ridel C, Didelot F, Herody M, et al. Macroscopic haematuria associated with sickle cell anaemia trait: Report of ten cases. Rev Med Intern 2002;23:690-5. 2. Baig MA, Lin YS, Rasheed J, Mittman. Renal medullareyt carcinoma. J Natl Med Assoc 2006;98:1171-4. 3. Kar BC. Clinical profile of sickle cell trait. J Assoc Physicians India 2002;50:1368-71. 4. Sesso R, Alme...

Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15-30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many...

background: until now, trimodal distribution of hbs has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. the rbc indices reduce as alpha-globin genes reduce in sickle cell trait (sct) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical course of the patien...

Massive intraocular hemorrhage developed in a child with advanced unilateral retinoblastoma after intrarterial treatment with Melphalan and Topotecan. The child tested positive for sickle cell trait. Sickle cell trait may predispose such children to slower vascular transit time, hypoxia, sickling and vascular occlusion caused by catheter induced decreased flow. Enucleation confirmed the ultraso...

An automated technique is described which is capable of detecting sickle-cell haemoglobin and differentiating the sickle-cell trait from sickle-cell anaemia. The method is based upon the Itano solubility test and utilizes Technicon equipment.