BACKGROUND In sub-Saharan Africa, more than 90% of children with sickle-cell anaemia die before the diagnosis can be made. The causes of death are poorly documented, but bacterial sepsis is probably important. We examined the risk of invasive bacterial diseases in children with sickle-cell anaemia. METHODS This study was undertaken in a rural area on the coast of Kenya, with a case-control ap...

1. Breen CP, Macdougall IC. Improvement of erythropoietin-resistant anaemia after renal transplantation in patients with homozygous sickle-cell disease. Nephrol Dial Transplant 1998; 13: 2949–2952 2. Tomson CRV, Edmunds ME, Chambers K et al. Effect of recombinant human erythropoietin on erythropoiesis in homozygous sickle-cell anaemia and renal failure. Nephrol Dial Transplant 1992; 7: 817–821 ...

The gastric acid response to the augmented histamine test was measured in 115 Ghanaian patients, including 45 cases of sickle-cell anaemia. Normal gastric acid responses were found in the patients with sickle-cell anaemia, suggesting that the frequent occurrence of indigestion in patients with this disorder is unlikely to be related to abnormal gastric acid secretion.

Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh sickle cell nephropathy, is an aggressive cancer seen almost exclusively in people with sickle cell disease with more than 160 cases reported worldwide, but only few cases were reported in patients with sickle cell anaemia (HBSS) and from Nigeria. Sarcomatoid renal c...

Sickle cell haemoglobin (HbS) results from an autosomal recessively inherited mutation in which the 17th nucleotide of the beta globin gene is changed from thymine to adenine and the amino acid glutamic acid is replaced by valine at position 6 in the beta globin chain. [1, 2]Sickle cells have a reduced deformability and are easily destroyed, causing occlusion of the microcirculation and a chron...

BACKGROUND Sickle cell anaemia is the most common genetic disorder worldwide as well as in Nigeria. Delay in the diagnosis of the condition constitutes an important cause of concern for caretakers of affected children. OBJECTIVE To determine the age at diagnosis in a population of children with sickle cell anaemia in Lagos, Nigeria. METHODOLOGY The study was conducted between October and De...

This review was designed to discuss the rare occurrence of diabetes mellitus (DM) in patients with sickle cell anaemia (SCA) a particular focus on factors, such as life expectancy, body weight, chronic inflammation, insulin resistance, glucose buffering property haemoglobin, and microRNAs (miRNAs), aiming stimulate research which will fill existing knowledge gaps regarding interplay between SCA...

BACKGROUND Sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. It is of interest to study its effect on red cell indices beside haemoglobin concentration. OBJECTIVES The objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia. METHODS we conducted a cross-sectional study including 97 chil...

Sickle cell anaemia is an autosomal recessive genetic condition producing abnormal haemoglobin HbS molecules that result in stiff and sticky red blood cells leading to unpredictable episodes of microvascular occlusions. The clinical and radiological manifestations of sickle cell anaemia result from small vessel occlusion, leading to tissue ischemia/infarction and progressive end-organ damage. I...