Gene diversity is sometimes estimated from samples that contain inbred or related individuals. If inbred or related individuals are included in a sample, then the standard estimator for gene diversity produces a downward bias caused by an inflation of the variance of estimated allele frequencies. We develop an unbiased estimator for gene diversity that relies on kinship coefficients for pairs o...

3D thinning algorithms are generally faster than any other connectivity-preservation skeletonization methods. However, most 3D thinning algorithms cannot guarantee to generate unit-width skeleton. This document describes an algorithm to generate unit-width skeleton based on 3D thinning and shortest path finding.

Establishing metadata requirements is a key challenge for any attempt to implement a digital preservation repository. The repository’s capacity to provide costeffective, trustworthy services largely derives from the metadata it uses. This paper describes the metadata posited to support services the Chronopolis preservation system will offer at the conclusion of its first year of development. Ch...

Phosphate-buffered sucrose (PBSc) solution is effective for short-term hypothermic preservation of tissue during feline kidney transplantation. A high-molecular-weight polyethylene glycol (35,000 Da, PEG35) reportedly enhanced the protective effects against cold-induced tubular injuries in animal kidney transplantation models. We investigated the ability of PBSc solution containing PEG35 to pre...

Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay method used for pancreas transplantation during the past 2 decades. Other solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for short preservation periods. But the advent of clinical islet transplantation and the larger use of controlled non–heart-beating donors have pro...

BACKGROUND Currently, it is challenging to treat massive bone defects of proximal tibia. Although numerous methods are available for reconstruction with epiphysis preservation, limitations in knee function and complications are noted with these methods. Our paper describes our attempt to reconstruct a marked defect in the proximal tibia with an uncemented three-dimensional (3D)-printed prosthes...