COPYRIGHT © 2013 JOHN WILEY & SONS Introduction Hypertension is common in people with diabetes. While ACE-inhibitors (ACE-Is) and angiotensin II receptor antagonists remain first-line antihypertensive agents, adequate blood pressure (BP) reduction may require two or three drugs including thiazide-like diuretics. Chlorthalidone was the diuretic used in several large diabetes hypertension studies...

Cardiovascular diseases are the most common causes of mortality, and hypertension is the most common cardiovascular disease in all ages. The Systolic Hypertension in the Elderly Program (SHEP) trial has shown that the pharmacologic reduction of isolated systolic hypertension can significantly reduce the incidence of cardiovascular complications. The aim of the Italian multicenter study reported...

SPARC is a matrix protein that mediates interactions between cells and the microenvironment. In cancer, SPARC may either promote or inhibit tumor growth depending upon the tumor type. In neuroblastoma, SPARC is expressed in the stromal Schwannian cells and functions as a tumor suppressor. Here, we developed a novel in vivo model of stroma-rich neuroblastoma using non-tumorigenic SHEP cells with...

У лекції розглядаються питання про роль тіазидних і тіазидоподібних діуретиків, зокрема хлорталідону, у сучасному лікуванні артеріальної гіпертензії (АГ). Наведено сучасні уявлення механізм дії діуретиків хлорталідону. Обговорені відмінності в ступені антигіпертензивного ефекту гідрохлортіазиду й Проаналізовані результати великих рандомізованих досліджень SHEP, MRFIT, ALLHAT, яких терапія хлорт...

The publication, in 1991, of the results of the Systolic Hypertension in the Elderly Program (SHEP) constituted a major therapeutic advance for treating isolated systolic hypertension–systolic blood pressure 160 to 219 mm Hg and diastolic blood pressure ,90 mm Hg in patients .60 years of age.1 The results demonstrated not only a decrease in strokes but also coronary heart disease. In earlier st...

OBJECTIVE To assess the role of treated diastolic blood pressure (DBP) level in stroke, coronary heart disease (CHD), and cardiovascular disease (CVD) in patients with isolated systolic hypertension (ISH). DESIGN An analysis of the 4736 participants in the Systolic Hypertension in the Elderly Program (SHEP) was undertaken. The SHEP was a randomized multicenter double-blind outpatient clinical...