To the Editor—Severe acute respiratory syndrome (SARS) emerged last year as a new infectious disease, as well as an occupational hazard for health care workers treating infected patients. The Centers for Disease Control and Prevention (CDC) recently drafted guidlines suggesting that routes of transmission of the SARS-associated coronavirus (CoV) involve the mucous membranes, such as the respira...

CHEST / 137 / 6 / JUNE, 201

Severe acute respiratory syndrome (SARS) is a new clinical entity which was first observed in Guangdong, China at the end of 2002. Since then there have been more than 7000 probable cases worldwide and more than 800 deaths. The difficulties of managing patients with this potentially fatal condition have been compounded by a lack of data relating to the condition and its highly infectious nature...

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health crisis in late 2019 and quickly spread across continents, disrupting societies, economies, healthcare systems worldwide. This article provides comprehensive review of pandemic's origins, epidemiology, clinical manifestations, impacts, various strategies implemented to mi...

In 2003, the onset of severe acute respiratory syndrome (SARS) caused worldwide chaos. Although SARS was eradicated by isolation towards the end of 2003, sporadic cases have been reported in Singapore, Taiwan and mainland China. In this review, SARS is discussed as a disease, as well as its diagnosis, management and pharmacotherapy. Respiratory physicians and healthcare professionals have to be...

despite improvement of mechanical ventilation devices for infants, lung injury still causes morbidity and mortality in many cases. to determine the effect of high frequency oscillatory ventilation (hfov) in infants with severe respiratory failure, 10 neonates were evaluated prospectively. mean gestational age of these patients was 35 weeks and alveolar-arterial oxygen gradient (a-ado2) and the ...

Acute hemorrhagic myonecrosis accompanied by severe inter- and intrafascicular edema and hemorrhage of the right gluteal area was diagnosed in a 13-year-old male thoroughbred horse. Once the muscular and fascicular changes were subsided, the horse then developed acute respiratory problem. Histologically, the lung had diffuse severe hemorrhage with mild neutrophilic infiltration. The cause of de...

Since the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection was reported on May 20, 2015 in Korea, there have been 186 laboratory-confirmed cases of MERS-CoV infection with 36 fatalities. Ninety-seven percent (181/186) of the cases had exposure to the health care facilities. We are reporting a superspreading event that transmitted MERS-CoV to 81 persons at...