We present an improved implementation of the Wagner-Whitin algorithm for economic lot-sizing problems based on the planning-horizon theorem and the Economic- Part-Period concept. The proposed method of this paper reduces the burden of the computations significantly in two different cases. We first assume there is no backlogging and inventory holding and set-up costs are fixed. The second model ...

In this paper we prove a general result concerning continuity of the blow-up time and the blow-up set for an evolution problem under perturbations. This result is based on some convergence of the perturbations for times smaller than the blow-up time of the unperturbed problem together with uniform bounds on the blow-up rates of the perturbed problems. We also present several examples. Among the...

We consider the problem of inferring kinetic mechanisms for biochemical reactions from time series data. Using a priori knowledge about the structure of chemical reaction kinetics we develop global nonlinear models which use elementary reactions as a basis set, and discuss model construction using top-down and bottom-up approaches.