نتایج جستجو برای: sesquiterpene coumarin

تعداد نتایج: 6204  

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2011
Samaneh Mollazadeh Maryam M Matin Ahmad Reza Bahrami Mehrdad Iranshahi Morteza Behnam-Rassouli Fatemeh B Rassouli Vajiheh Neshati

Transitional cell carcinoma (TCC), which is the most common type of bladder cancer, shows resistance to chemotherapeutic agents due to the overexpression of drug efflux pumps. In this study, the effects of feselol, a sesquiterpene coumarin extracted from Ferula badrakema, on cisplatin cytotoxicity were investigated in 5637 cells, a TCC subline. Cell viability and DNA lesion were evaluated by th...

A. Hosseini* F. Ahmadi F. Jafari N. Ghiasvand S. Javaheri Y. Shokoohinia

Background and objectives: Interaction of compounds with ct-DNA can affect the replication, protein synthesis and cell division. Different species of the genus Ferula (Apiaceae) have shown various biomedical applications for many centuries. Biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflamm...

Journal: :Phytochemistry 2007
Ahmed A Ahmed Mohamed-Elamir F Hegazy Amar Zellagui Salah Rhouati Tarik A Mohamed Ahmed A Sayed Mohamed A Abdella Shinji Ohta Toshifumi Hirata

Fractionation of methylene chloride extracts of the resin of Ferula vesceritensis and F. sinaica afforded three sesquiterpene coumarins and a glucose derivative. One of them was a sesquiterpene with a rare carbon skeleton. The structures of these compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, and HMBC.

Journal: :Molecules 2017
Ana F R Cerqueira Vítor A S Almodôvar Maria G P M S Neves Augusto C Tomé

This review covers the synthesis of coumarin-porphyrin, coumarin-phthalocyanine and coumarin-corrole conjugates and their potential applications. While coumarin-phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin-functionalized phthalonitriles, coumarin-porphyrin and coumarin-corrole conjugates were prepared by complementary approaches: (a) direct synthesis...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1997
S L Born P A Rodriguez C L Eddy L D Lehman-McKeeman

Coumarin is used widely as a fragrance constituent and is administered clinically in the treatment of certain lymphedemas and malignancies. Although toxicity occurs only rarely in humans treated clinically with high-dose coumarin, it is well established that coumarin is hepatotoxic in the rat. This species difference in susceptibility to toxicity reflects the disparate metabolic processes occur...

Dian Ratih Laksmitawati Maesaroh Maesaroh, Moordiani Moordiani, Ni Made Dwi Sandhiutami Nurul Fauziah, Wahyu Widowati,

Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
S L Born J K Hu L D Lehman-McKeeman

o-Hydroxyphenylacetaldehyde (o-HPA), the product of coumarin 3, 4-epoxide, was synthesized and its contribution to the hepatotoxic effects of coumarin in the rat was determined. The relative toxicity of coumarin and o-HPA were initially assessed in Chinese hamster ovary K1 (CHO K1) cells, a cell line that does not contain cytochrome P450. In CHO K1 cells, o-HPA-mediated toxicity greatly exceede...

Journal: :avicenna journal of phytomedicine 0
kobra shirani department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran javad behravan biotechnology research center and pharmacy school, mashhad university of medical sciences, mashhad, i. r. iran fatemeh mosaffa biotechnology research center and pharmacy school, mashhad university of medical sciences, mashhad, i. r. iran mehrdad iranshahi department of pharmacognosy and biotechnology, faculty of pharmacy, mashhad university of medical sciences, i. r. iran babak mehmankhah department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran kamal razavi-azarkhiavi department of pharmacodynamy and toxicology, faculty of pharmacy, mashhad university of medical sciences, mashhad, i. r. iran

objective: ferula szowitsiana has been widely used for medicinal purposes around the world. the anti-oxidant effect of f.szowitsiana had been proved. the current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from f. szowitsiana, against hydrogen peroxide (h2o2) - induced oxidative dna damage in human lymphocytes. materials and methods: human lymphocyt...

Journal: :iranian journal of pharmaceutical research 0
bs fazly bazzaz m iranshahi m iranshahi m naderinasab m khajeh karamodin

the plant kingdom constitutes a source of new chemical compounds, which may be important due to their potential uses in medicine, or their other biological properties. in this study, the effects of galbanic acid (ga), a sesquiterpene coumarin from roots of ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates of staphylococcus aureus. isolates of s. ...

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