Substantial data are available to indicate that the diet influences serum levels of cholesterol and lipoproteins. These data are derived from studies in laboratory animals, from epidemiologic studies, and from human investigations. Most research has focused on effects of diet on serum total cholesterol concentrations. In recent years, however, attention has shifted to individual lipoproteins, i...

Migrant and experimental animal studies suggest that differences in breast cancer incidence rates may be related, in part, to intake of dietary fat. The experimental evidence indicates that total fat, saturated, and n-6 polyunsaturated fatty acids (PUFAs) may stimulate both mammary tumor growth and metastasis, whereas n-3 PUFAs may have a tumor-inhibiting effect. Overall, epidemiological studie...

A general impairment of liver mitochondrial enzymes is central to Reye's syndrome (RS). The respiration of isolated liver mitochondria was measured after the addition of concentrated normal serum or RS serum derived from 12 patients. RS serum stimulates oxygen consumption in isolated rat liver mitochondria. This effect is due to the oxidation of uric acid by peroxisomes contaminating the prepar...

Previous studies on human serum phospholipids have dealt with concentration in whole serum (l-3). With the introduction of the concept of lipoproteins (4) and lipoprotein classes (5) it became of interest to study the phospholipids of serum as structural units of these macromolecules. Whereas there is now agreement on the relative proportions of the phospholipid species in whole serum, it has n...

Previous studies on human serum phospholipids have dealt with concentration in whole serum (l-3). With the introduction of the concept of lipoproteins (4) and lipoprotein classes (5) it became of interest to study the phospholipids of serum as structural units of these macromolecules. Whereas there is now agreement on the relative proportions of the phospholipid species in whole serum, it has n...

The effects of increasing levels of Fe on serum fatty acids, cholesterol, triacylglycerol, liver and heart were examined in male Sprague-Dawley rats fed either Fe-deficient or carbonyl Fe-supplemented diets with 35 (control), 350, 3500 and 20 000 microg Fe/g for 12 weeks. As intake of Fe increased, serum total cholesterol increased from 2.0 mmol/l in controls to 5.2 mmol/l at the highest level ...

BACKGROUND AND AIMS Ulcerative colitis (UC) is associated with increased dietary intake of fat and n-6 polyunsaturated fatty acids (PUFA). Modification of fat metabolism may alter inflammation and disease severity. Our aim was to assess differences in dietary and serum fatty acid levels between control and UC subjects and associations with disease activity and inflammatory cytokines. METHODS ...

BACKGROUND The National Nutritional Survey in Japan (NNSJ) was initiated in 1946. Using the majority of the participants for NNSJ, the National Survey on Circulatory Disorders (NSCD) has been conducted every 10 year since 1960. We compared fatty acids intakes obtained from NNSJ and serum lipid profiles from NSCD conducted in 1990. METHODS A total of 8344 community residents (4856 women and 34...

The fatty acids pattern of the total lipid fractions of male rat serum and seminal fluids were studied under the effect of gossypol and some of its metabolites (Apogossypol and gossypolone). The applied dose of gossypol and its derivatives exhibits some metabolic effects such as significant decrease of the saturated fatty acids and a significant increase of polyunsaturated fatty acids. In the s...