This study evaluated the effects of Mesobuthus eupeus (Me) scorpion venom on inflammatory response following injection. Additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after Me venom inoculation. Animals were divided randomly into four groups: the first group received LD50 of venom and the second and third gro...

conclusions according to the results, brucellosis has remained endemic in this region. most cases were detected by elisa igg. the highest kappa agreements were between tests krb-sat, krb-igg and ksat-igg, while the lowest levels of agreement were between tests sat-igm and elisa igm-igg. considering that elisa igm results are covered by sat and elisa igg test results, applications of this test d...

Brain-derived neurotrophic factor (BDNF) is a major orchestrator of exercise-induced brain plasticity and circulating (peripheral) BDNF may have central effects. Approximately 99% of circulating BDNF is platelet-bound, and at rest ~30% of circulating platelets are stored in the spleen. Interestingly, forearm handgrip exercise significantly elevates sympathetic outflow and has been shown to indu...

this study evaluated the effects of mesobuthus eupeus (me) scorpion venom on inflammatory response following injection. additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after me venom inoculation. animals were divided randomly into four groups: the first group received ld50 of venom and the second and third gro...

Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabolized by cytochrome P450 2E1 to various phenolic metabolites which accumulate in the bone marrow. Bone marrow contains high levels of myeloperoxidase which can catalyze the further metabolism of the phenolic metabolites to reactive free radical species. Redox cycling of these free radical species pr...

The in vivo metabolism and DMA binding of benzo(a)pyrene (BP) was examined in male Sprague-Dawley rat. BP was ad ministered i.v. at dose levels of 1.0 and 10.0 /¿mol/kg. DNA samples from [3H]BP-treated rats were enzymatically digested to deoxyribonucleosides and analyzed by high-pressure liquid chromatography. Several chromatographically distinct nucleoside-bound adducts were observed in lung ...

The mode of action of 2-mercaptoethanol (2-ME) on the primary immune response in vitro was investigated. Fetal calf serum (FCS) was preincubated with 2-ME and lyophilized to remove free 2-ME. This 2-ME-treated FCS was able to substitute the function of adherent cells in the primary immune response against sheep red blood cells (SRBC) in vitro; Fractionation of 2-tme-treated FCS on a Sephadex G-...

Aim: In the diagnosis of brucellosis, production microorganisms in blood or bone marrow culture is considered gold standard. But it not always possible to produce microorganism. For this reason, serological tests are used diagnose brucellosis. Rose Bengal test (RB), Standard Tube Agglutination (STA), Coombs Test (CT) and 2-Mercaptoethanol (2-ME) common methods. Immunocapture-agglutination (ICA)...

Recent studies have suggested that Mentha longifolia L. extracts (ME) have anti-inflammatory and antioxidant activities. In this paper, we attempted to determine the effect of ME in a rat stroke model. Five groups of experimental animals were used (n=14); the first and second groups (control and sham, respectively) received intraperitoneal injections of daily-distilled water; the other three gr...

It has been reported by many authors that a variety of thiol compounds augment various lymphocyte reactions in vitro, including antibody responses (1, 2), induction of cytotoxic T cells in the mixed lymphocyte culture (3, 4), and the DNA synthetic response to mitogens (5-7). 2-Mercaptoethanol (2-ME), 1 one of the most effective thiols, was shown to be a polyclonal activator of both T cells (8) ...