Abstract Aim Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA) compared to the general population. Several recent studies have indicated that pentraxin 3 (PTX-3) and cell adhesion molecules (CAMs) might be independent biomarkers of subclinical atherosclerosis. In this study, we aimed determine relationship CAMs PTX-3 carotid intima media thickness (CIMT) PsA compa...

Primary and reactivated Epstein-Barr virus (EBV) infections after organ transplantation are associated with the development of posttransplant lymphoproliferative malignancies. Since viral reactivation frequently stays asymptomatic, early diagnosis and treatment are challenges during posttransplant patient monitoring. Both soluble-CD23 (sCD23) and intercellular adhesion molecule 1 (ICAM-1) cell ...

Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein and a major ligand for the integrin leukocyte function-associated antigen1 (LFA-1). The interaction between ICAM-1 and LFA-1 plays an important role in many lymphocyte activities during inflammatory and immunological reactions. Recently, a soluble form of ICAM-1 (SICAM-1) has been detected in normal serum [ 13 and we hav...

BACKGROUND The natural course of sarcoidosis is variable, but no single parameter has been generally accepted as a good marker for disease activity. Adhesion molecules are required for the migration of inflammatory cells; thus, they may be markers of activity in sarcoidosis. METHODS In 16 patients with active sarcoidosis and 11 with inactive disease (10 were male, 17 were female; mean age [-/...

UNLABELLED Immunological disturbances have been implicated in the pathogenesis of some neurodegenerative disorders like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Adhesion molecules are markers of activated endothelial cells upregulated by action of cytokines. MATERIALS AND METHODS To investigate the activation or not of the vascular cells in AD and ALS, serum soluble i...

Here we compared effect of serum from varicose patients undergoing endovenous laser ablation (EVLA) and classic vein stripping (CVS) on biological properties of endothelial cells and on the local and systemic profiles of proinflammatory agents. Results showed that serum from EVLA patients improved proliferation and reduced senescence and oxidative stress in the endothelial cells, as compared wi...

BACKGROUND Adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) are thought to contribute to the airway inflammation and airway hyper-responsiveness (AHR) of allergic asthma. Some differences from allergic asthma have been noted, including airway neutrophilia, and the involvement of ICAM-1 in toluene diisocyanate (TDI) asthma is currently unclear. OBJECTIVE We utilized mice l...

cular disease (3 ). Such high concentrations of circulating adhesion molecules may be of interest for diagnostic and prognostic purposes, as demonstrated for ICAM-1 and P-selectin, which provide useful information in healthy individuals and in patients with cardiovascular diseases (9 ). However, reference values for healthy children and adults have not been defined. In the current study, we mea...

Although the role of endothelium in varicose vein development is indisputable, the effect of the pathology on biological properties of endothelial cells remains unclear. Here we examined if the presence of varicose veins affects senescence of endothelial cells (HUVECs) and, if so, what will be the local and systemic outcome of this effect. Experiments showed that HUVECs subjected to serum from ...