Patients and Methods: Ninety children with beta-thalassemia major (55 males and 35 females) with a mean age of 7.17±3.78 years (1-13 years) and age and sex matched control group of 60 healthy children (36 males and 24 females) with a mean age 6.98±3.66 years (1-13) years. Serum parathyroid hormone (PTH), serum total Calcium (Ca), serum phosphorus (P), serum alkaline phosphatase (ALP), serum 25-...

A one-step, single use, disposable Alkaline Phosphatase (ALP) biosensor has been developed. It is based on the detection of phenol produced by an ALP enzymatic reaction. It can operate at 25 °C in a pH 10 medium. It measures ALP of 0-300 IU/L. The permissible concentrations of glucose, ascorbic acid and urea without interference are 10 mM/L, 5 mg/L and 400 mg/L, respectively. Experimental resul...

Alkaline phosphatase (ALP) flare phenomenon documented as scintigraphic flare phenomenon due to elevated serum ALP levels produced by osteoblasts reflects an osteoblastic reaction in response to the effective therapy of non-small cell lung cancer (NSCLC). Here, we report a case of ALP flare following gefitinib treatment for NSCLC. We also retrospectively analyzed the prevalence of ALP flare in ...

This two-site IRMA includes specific monoclonal antibodies for measuring skeletal alkaline phosphatase (B-ALP) in human serum. Assay calibration is based on mass units (micrograms per liter) and was established with purified B-ALP from a human osteosarcoma cell line, SAOS-2. Precision studies demonstrated intra- and interassay CVs of 3-5% and 5-7%, respectively. Relative reactivity studies show...

The optical response of an alkaline phosphatase (ALP) probe was evaluated against various bacterial species.

BACKGROUND Breast cancer is the commonest malignancy of women in Nigeria. Change in serum levels of some biochemical parameters could assist diagnosis and follow-up of breast cancer. OBJECTIVE To determine serum levels of calcium, inorganic phosphates, alkaline phosphatase (ALP) and acid phosphatase (ACP) activities in patients with breast cancer, and change in the serum levels over time. M...

Putative standards of skeletal alkaline phosphatase (ALP) (from bone, bone cells, osteosarcoma cells, and Pagetic serum) and hepatic ALP (from cholestatic serum and bile) were used to compare three methods for quantifying skeletal ALP activity in serum: heat inactivation, precipitation with wheat germ agglutinin (WGA), and precipitation with concanavalin A (Con A). All the skeletal ALP standard...

background: garcinia kola seed is consumed indiscriminately in nigeria without recourse to its potential toxicity. therefore, this study was aimed at assessing the toxicity of the aqueous extract of g. kola seeds on selected tissues of male rats.  methods: thirty male rats (215.00 ± 18.58 g) were assigned into four groups: a, b, c and d which received 0.5 ml of distilled water, 25, 50 and 100 m...

.. Background: This study was carried out to determine the role of total serum alkaline Phosphatase in bone metastasis among patients of breast cancer. Setting; Department of Surgery, Nishtar Medical University, Multan in collaboration with breast clinic MINAR. Study Duration; January 2016 to June 2017 Subjects and methods; It was a retrospective study carried out at breast clinic MINAR, Multan...

The present study examined the impact of Lufenuron on biochemical parameters of albino mice.The biochemical parameters such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) and Total protein in serum were observed. The mice exposed with Lufenuron 0.1520 mg/kg) for 30 days. The present study suggests that the level of AST, ALT and ALP were increa...