Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...

N Engl J Med 2005;352:1112-20. Copyright © 2005 Massachusetts Medical Society. he serotonin syndrome is a potentially life-threatening adverse drug reaction that results from therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs. Three features of the serotonin syndrome are critical to an understanding of the disorder. First, the serotonin syndrome is not a...

Poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. Proper diagnosis is the cornerstone for optimal management of poisoned patients. Since the definitive analytical confirmation of the nature of the toxicant involved in the poisoning cannot be rapidly obtained in the majority of healthcare facilities, diagnosis relies on the medical histo...

Serotonin syndrome, a triad of autonomic instability, altered mental status and neuromuscular abnormalities, is usually attributed to serotonergic overdoses. Moclobemide is a new selective monoamine oxidase inhibitor (MAOI) that generally causes mild, self-limited gastrointestinal and central nervous system effects after ingestion. We present a case of serotonin syndrome that occurred after moc...

Objective: To report a unique case of fluoxetine overdose leading to serotonin syndrome with auditory and complex visual hallucinations. This case also demonstrates serotonin syndrome may mimic a Parkinsonian syndrome, which is poorly described in the literature. Case Summary: A 65-year-old gentleman, undergoing evaluation for possible Parkinsonian syndrome with bradykinesia and rigidity presen...

BMJ | 1 MARCH 2014 | VOLUME 348 33 NSW Poisons Information Centre, Sydney, Australia Sydney Medical School, University of Sydney, NSW 2006 Department of Clinical Toxicology, Royal Prince Alfred Hospital, Sydney School of Medicine and Public Health, University of Newcastle, Newcastle, Australia Correspondence to: N A Buckley [email protected] Cite this as: BMJ 2014;348:g1626 doi: 10.1136/bmj...

The serotonin syndrome is a toxic state largely attributable to changes in sensitivity of serotonin receptor system in the brainstem and spinal cord resulting from increased serotonergic activity in central neurologic system, due to use of serotonergic agents either in overdose or in combination. Serotonin syndrome may present with neuromuscular (clonus, myoclonus, tremor, hyperreflexia) and au...