Serological diagnosis of an acute infection can be done by the demonstration of seroconversion and/or agent-specific IgM antibodies in the serum samples. Seroconversion describes 4 fold or more increase in antibody levels of the serum samples which is collected at the acute and convelescent phase (10-15 days intervals) of an infection. As the detection of seroconversion is time-consuming, the a...

It is rather curious that, although ser for a multitude of constituents in and haematological laboratories, the ter has come to imply almost exclusively the ( of serum for antibodies, and, in part bodies related to microbial diseases serological techniques tend to be regarde as the prerogative of microbiologists. When one considers for how long a extent in biochemical laboratories the of tests ...

OBJECTIVE Recent studies have identified a set of serological markers for telomere dysfunction and DNA damage. The relevance of these serological markers in type 2 diabetes remains elusive. We investigated the association of serological markers (elongation factor 1α [EF-1α], stathmin, and N-acetyl-glucosaminidase) with leukocyte telomere length, a functional variant of uncoupling protein-2 (UCP...

We present a case of probable tuberculous meningitis in which serological changes 'diagnostic' of herpes simplex encephalitis were found. Evidence is provided that the serological changes in this case represent a true false positive, and that reliance on clinical plus serological criteria to diagnose herpes simplex encephalitis could result in failure to diagnose and treat tuberculous meningitis.

BACKGROUND Syphilis remains a global public health threat and can lead to severe complications. In addition to resolution of clinical manifestations, a reduction in nontreponemal antibody titers after treatment is regarded as "proof of cure." However, some patients manifest < 4-fold decline ("serological non-response") or persistently positive nontreponemal titers despite an appropriate decline...

Schmidt, Jean M. (State University of Iowa, Iowa City) and Robert L. Richardson. Serology of Bacterionema matruchotii. J. Bacteriol. 83:584-589. 1962.-Serological relationships of Bacterionema matruchotii were studied by means of the complement-fixation reaction. A common complement-fixing antigen was demonstrated in 37 strains of this organism. Serological relationships to species in the gener...

Serological tests for tuberculosis are inaccurate and WHO has recommended against their use. Although not used by the Revised National TB Control Programme (RNTCP), serodiagnostics are widely used in the private sector in India. A root-cause analysis was undertaken to determine why serological tests are so popular, and seven root causes were identified that can be grouped into three categories:...

Serological testing is widely used to monitor swine herds for Actinobacillus pleuropneumoniae (APP). Several serological tests are presently used, most often the complement fixation test, the long-chain lipopolysaccharide enzyme-linked immunosorbent assay (ELISA), and the ApxIV ELISA. Serological testing occasionally generates ambiguous results. In such situations, bacterial isolation and polym...

Strategies for the prevention of cancer include those aimed at reducing the incidence of cancer (primary prevention) and cancer mortality through early detection of tumors (secondary prevention). The efficacy of prevention interventions is evaluated by clinical trials. The conduct of clinical trials is aided by the use of serological indicators of the carcino genic process measured using plasma...

Background Some syphilitic patients remain in a serologically positive state after the recommended therapy. Although we often retreat patients in clinical practice, the optimal treatment protocol remains uncertain due to the paucity of data regarding serological response to retreatment and long-term outcomes. Methods We examined rapid plasma reagin serological test results of 70 serofast earl...