Epidemiological studies have demonstrated the cancer protective effects of dietary agents and other natural compounds isolated from fruits, soybeans, and vegetables on neoplasia. Studies have also revealed the potential for these natural products to be combined with chemotherapy or radiotherapy for the more effective treatment of cancer. In this paper we discuss the potential for targeting the ...

In the last three decades, gemcitabine has progressed from the status of a laboratory cytotoxic drug to a standard clinical chemotherapeutic agent and a potent radiation sensitizer. In an effort to improve the efficacy of gemcitabine, additional chemotherapeutic agents have been combined with gemcitabine (both with and without radiation) but with toxicity proving to be a major limitation. There...

The peripheral mechanism of hyperalgesia is considered to be the result of nociceptor sensitization. As possible agents causing nociceptor sensitization, bradykinin, histamine, prostaglandin (PG)s, protons and nerve growth factor are evaluated with respect to their release into the injured tissue, their sensitizing potencies. Whether blocking these agents suppresses sensitization was also evalu...

Abstract Background To enhance the performance of radiotherapy, emerging nanoparticles that can professionally X-ray irradiation to destruct cancer cells are extremely necessary. Here, we examined potential PEG-coated magnetite copper sulfide hetero-nanoparticles (Fe 3 O 4 @Cus–PEG) as a radiosensitizer agent. Methods Fe @Cus–PEG were synthesized and characterized. The toxicity on HT-29 colorec...

OBJECTIVES To detect common skin-sensitizing agents among patients experiencing allergic contact dermatitis (ACD). Methods: This was a retrospective study of 152 patients with clinically suspected ACD who underwent patch testing in an allergy clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 2012 and February 2015. Of these patients, only 74 (48%) patien...

Cancer cells acquire drug resistance via various mechanisms including enhanced cellular cytoprotective and antioxidant activities. Heme oxygenase-1 (HO-1) is a key enzyme exerting potent cytoprotection, cell proliferation and drug resistance. We aimed to investigate roles of HO-1 in human cholangiocarcinoma (CCA) cells for cytoprotection against chemotherapeutic agents. KKU-100 and KKU-M214 CCA...

Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. Diagnosis can be difficult because the signs and symptoms can be subtle and varied. These may include hirsutism, infertility, menstrual irregularities, and biochemical abnormalities, most notably insulin resistance. Treatment should target specific manifestations and individualized pa...