Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.   Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n...

objective: asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. to test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of crocus sativus (c. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats. materials and methods: to induce experimental asthma, rat...

objectives: in previous studies the therapeutic effects of nigella sativa have been demonstrated on asthmatic animals. in the present study, the preventive effect of single dose of alpha-hederin, its active constituent, has been evaluated on lung inflammation and some inflammatory mediators in lungs of ovalbumin sensitized rat in order to elicit its mechanism. materials and methods: forty rats ...

objective(s):cefixime (cfx), is a semi-synthetic third-generation oral cephalosporin antibiotic that is prescribed for the treatment of susceptible infections. there are some procedures for the determination of cfx in pharmaceutical formulations and biological samples. herein a spectrofluorimetric method was proposed for cfx determination based on the fluorescence quenching of terbium-danofloxa...

conclusions: these results indicate preventive effects of all natural adjuvants (especially g2) on pathological changes of the lung in sensitized guinea pigs. results: all pathological changes in s group including the eosinophil infiltration (scoring 3.28 ± 0.28), lymphocyte infiltration (2.82 ± 0.26), local epithelial necrosis (2.71 ± 0.47) and mucosal plug (2.75 ± 0.37) were significantly hig...

new kinds of hydroquinone derivatives were synthesized and along with a azo dye applied as additives in the iodide/iodine redox electrolyte for dye-sensitized solar cells and their effect on the short-circuit photocurrent of dye sensitized solar cells was investigated. addition of 0.05 m a hydroquinone derivative in the electrolyte comprising 0.5 m 1-methyl-3-propylimidazolium iodide (mpii) and...

the aim of this study was to investigate the effects of nigella sativa  (ns) fixed oil in comparison to dexamethasone (dex) on inducible nitric oxide synthase (inos), peripheral blood eosinophils (pbe), allergen specific serum igg1 and interleukins and airway inflammation in a murine model of allergic asthma. thirty-one mice were divided into four groups. group  i (n =  6) served as the control...

Abstract A new method to synthesize complexes of the type [(CNC)Ru II (NN)L] n+ has been introduced, where CNC is a tridentate pincer composed two (benz)imidazole derived NHC rings and pyridyl ring, NN bidentate aromatic diimine ligand, L=bromide or acetonitrile, n=1 2. Following this series six synthesized characterized by spectroscopic, analytic, crystallographic, computational methods. Their...

objective: the anxiety profile in the stimulant-sensitized animals is not clear. thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (meth) on the anxiety profile. the aim of this study was to examine whether meth-sensitized rats would show an increase in the expression of anxiogenic-like behaviors and to determine whether a low dose of...