Senna leaf (Cassia acutifolia) is a plant that widely known by the public to treat constipation. products have weaknesses in form of an unpleasant aroma and taste use inappropriate doses. This study aims determine effect variations levels lactose mannitol as filler on physical properties effervescent granules senna extract. Effervescent were made using melting method with ratio 25% : 75%, 50% 5...