BACKGROUND Findings from animal models suggest that selenium supplementation improves glucose metabolism. OBJECTIVE To examine the effect of long-term selenium supplementation on the incidence of type 2 diabetes. DESIGN Secondary analysis of a randomized, double-blind, placebo-controlled trial. SETTING Areas of low selenium consumption of the eastern United States. PATIENTS 1202 persons...

OBJECTIVE Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective of this study is to investigate the effect of selenium supplementation in different doses on thyroid function, under conditions of suboptimal dietary selenium intake. DESIGN The Danish PREvention of Cancer by Intervention with SElenium pilot study (DK-PRECISE) is ...

An experiment was conducted to evaluate the effects of high dietary levels of selenium (as sodium selenite) and copper (as copper sulphate) on growth performance, serum biochemical parameters and antibody production against Newcastle disease vaccine (NDV) virus in broiler chickens. A total of 160 Ross 308 unsexed day old broiler chickens were randomly allocated into four treatment groups (n=40 ...

The influence of selenium supplementation during chelation therapy to reduce body burden and toxicity of lead was investigated in rats. Selenium had marginal effects on liver, kidney and blood lead decorporation by calcium disodium ethylenediamine tetra acetic acid (CaNa2EDTA) and activation of inhibited delta- aminolevulinic acid dehydratase (ALAD) activity by calcium trisodium diethylenetriam...

The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementatio...

BACKGROUND Selenium is part of the antioxidant defence system in animals and humans. The available selenium concentration in soil is low in many regions of the world. The purpose of this study was to evaluate the effect of organic versus inorganic selenium supplementation on selenium status of ewes, their lambs, and slaughter lambs. METHODS Ewes on four organic farms were allocated five or si...

The selenium concentration in milk was very low irrespective of whether there had been a selenium supplementation or not (4.5 and 5.1 μg/l, respectively). This was partly supposed to be caused by a low degree of supplementation, and partly by the fact that selenite – at least in comparison to organic selenium compounds – has been found to be relatively inefficient for increasing the selenium co...

This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is to determine the effectiveness of selenium only supplementation for the primary prevention of CVD. We will also determine potential adverse effects of selenium only supplementation on major CVD risk factors, such as blood pressure, blood lipids and type 2 diabetes. Results will be...

BACKGROUND Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully. OBJE...

background: studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (nafld). however, the effects of zinc and selenium co-supplementation before and/or after disease progression on nafld are not clear enough. the aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on nafld prognos...