PAX6 is a transcription factor that plays a major role in ocular morphogenesis. PAX6 is expressed in the eye, central nervous system and pancreas. Two alternative promoters, P0 and P1, which are differentially regulated during development, drive PAX6 transcription. We identified a 57 bp cis-regulatory element in exon 1 of the human PAX6 gene exon 1 enhancer (EIE). EIE enhances P1-driven PAX6 ex...

A new way of dynamical understanding of brain function of somatosensory evoked magnetic fields (SEF) is proposed by using the decorrelation method of independent component analysis (ICA) and our blind identification method of transfer functions based on feedback system theory. Magnetoencephalography (MEG) data are analyzed at special frequency by the decorrelation method of ICA, and two compone...

Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of fibrosarcoma. It is a mesenchymal neoplasm composed of round to oval cells dispersed in a nestlike or cordlike distribution on a highly collagenous tissue background and is now recognized as a distinct clinical entity. In this report we discuss the presentation, diagnosis, and treatment of SEF. We focus on the unique histologic and ...

biomechanical properties of soft tissue, such as liver, are important in modeling computer aided surgical procedures. experimental evidences show that liver tissue is transversely isotropic. in this article, considering the liver tissue as an incompressible fiber-reinforced composite with one family of fibers, an exponential strain energy function (sef) is proposed. the proposed sef is based on...

The outcomes of many decisions are uncertain and therefore need to be evaluated. We studied this evaluation process by recording neuronal activity in the supplementary eye field (SEF) during an oculomotor gambling task. While the monkeys awaited the outcome, SEF neurons represented attributes of the chosen option, namely, its expected value and the uncertainty of this value signal. After the ga...

1. Introduction The cerebral representation of pain perception in humans is poorly understood compared with that of other sensations such as touch or vibration. This is mainly because of a lack of appropriate instrumentation for stimulation and recording [1]. To our knowledge, only a few systematic studies of somatosensory evoked magnetic field (SEF) following painful stimulation (pain-related ...

Data interchange in the form of a standard exchange format(SEF) is only a first step towards tool interoperability. Inter-tool communication using files is slow and cumbersome; a better approach would be an application program interface, or API, that allowed tools to communicate with each other directly. This paper argues such an AP is a logical next step that builds on the current drive toward...

The latency and variability of latency of single-unit responses to identical visual stimulation were measured in the frontal eye field (FEF), supplementary eye field (SEF), and anterior cingulate cortex (ACC) of macaque monkeys performing visually guided saccades. The mean visual response latency was significantly shorter in FEF (64 ms) than in SEF (81 ms) or ACC (100 ms), and latency values de...

Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain controversial. Here, we study two extremely rare patients with microlesions o...

The supplementary eye field (SEF) is a region within medial frontal cortex that integrates complex visuospatial information and controls eye-head gaze shifts. Here, we test if the SEF encodes desired gaze directions in a simple retinal (eye-centered) frame, such as the superior colliculus, or in some other, more complex frame. We electrically stimulated 55 SEF sites in two head-unrestrained mon...