background : ascaridia galli , the largest nematode of small intestine of birds, especially the native poultry, may give rise to serious illness, pathological defects and economical losses even in modern poultry production systems. although various measures have been undertaken to vaccinate poultry against a.galli , no satisfactory results were obtained so far. however, there is no report on th...

background: to evaluate the immunological properties of leishmania major excreted- secreted (e-s) products on the progress of leishmaniasis in susceptible balb/c mice. methods: promastigotes of the leishmania major were cultured and e-s products were collected during the culture preiod. groups of balb/c mice (n= 12) were immunized with e-s products or whole antigen. animals were challenged with...

in the present study, pancreas glands in mehraban breed of female sheep were histomorphometricallystudied in four different age groups included: fetus, newborn, sexually mature and old ages. the results ofhistomorphometrical analysis with regard to frequency and percentage of parenchymal and stromal structures such as, exocrine secretory units, secretory ducts, blood vessels, islets of langerha...

The protein secretory machinery in Eukarya is involved in post-translational modification (PTMs) and sorting of the secretory and many transmembrane proteins. While the secretory machinery has been well-studied using classic reductionist approaches, a holistic view of its complex nature is lacking. Here, we present the first genome-scale model for the yeast secretory machinery which captures th...

Astrocytes are housekeepers of the central nervous system (CNS) and are important for CNS development, homeostasis and defence. They communicate with neurones and other glial cells through the release of signalling molecules. Astrocytes secrete a wide array of classic neurotransmitters, neuromodulators and hormones, as well as metabolic, trophic and plastic factors, all of which contribute to t...

High-level production of secretory proteins in Bacillus subtilis leads to a stress response involving the two-component system CssRS and its target genes htrA and htrB. Here, we used this sensing system in a reporter strain in which gfp is under control of P(htrA) , the secretion stress responsive promoter of htrA. Overexpression of heterologous secretory proteins in this strain results in gree...