objective: the effect of interleukin (il)-29, a new therapeutic agent similar to type i interferons (ifns), on ifn-α secretion of human plasmacytoid dendritic cells (pdcs) has not been studied. therefore, in this study, we aimed to clarify the effect of il-29 on ifn-α secretion of pdcs using human peripheral blood mononuclear cells (pbmcs) in the presence of cytosine-phosphate-guanosinemotif-co...

It has been shown that those factors which affect gastric acid secretion through the ventromedial and lateral nuclei of hypothalamus, can significantly alter centrally-mediated secretion. There is much evidence that glucose is among these factors that through a central mechanism can decrease induced acid secretion. It appears that this effect is mediated through glucose-sensitive neurons within...

objective(s):some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. incidence of these condition increases with aging. on the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (nos) activity is also altered in diabetes. in this study, modification in the enzyme activity associated with aging a...

noise is considered as one of the most severe sources of environmental and workplace constraints. many noise effects are well known on immune function, hormonal levels, cardiovascular and respiratory systems. in this study, our aim is to evaluate the effects of traffic noise exposure on basal and stimulated gastric pepsin secretion. 48 male rats were exposed to traffic noise (86 db) for a short...

the effect of epinephrine on triacylglycerol secretion was investigated in isolated rat hepatocytes. the effect appeared at concentrations of more than 1 µm and reached a plateau at 10 µm. epinephrine concentration for half of the maximal bioeffect (ec50) was about 1 µm. epineplrrine at a concentration of 10 µm suppressed triacylglycerol secretion by 33% and increased its cellular content by ap...

Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...

the chemical nature of secretion by the stigma and transmitting tissue in datura stramoniumwas studied by light microscopy using sudan black b, coomasie brilliant blue (cbb), toluidine blue,safranin, and pas. the stigmatic secretion reacted positively for lipids. during development, stigmaticcells became separated and intracellular lipids were transferred to intercellular spaces where theygradu...

background many studies have shown that h2s protects the gastric mucosa on different models of stress but till now there are few studies about the effects of h2s on gastric acid secretion. therefore, the aim of the present study was to investigate the role of autonomic nervous system in mediating the inhibitory effect of hydrogen sulfide donor (nahs) on stimulated gastric acid secretion in rats...