mann (Ewing, 1928) contends that since all epithelial tumours arise from the basal cells the term basal-cell carcinoma was not quite suitable. But Krompecher's choice of term may be justified on the ground that basal-cell epithelioma is composed of basal cells which retain their morphological characters throughout their existence, in contrast to the squamous-cell carcinoma in which the basal ce...

from the Clinical History.--The patient, female, aged thirty years, was admitted to St. Joseph's Hospital. Two years and three months ago she first noticed a small, hard tumor near the first bicuspid tooth on the left side of the lower jaw bone. It grew slowly. In childhood there was nothing unusual about her teeth, which were perfectly regular and even up to the time of her present illness. Ex...

In individuals with primary cutaneous epithelioma there may be a widespread predisposition of the basal cell layer of the epidermis toward the production of growths of this type. The differential diagnosis usually can be made on clinical characteristics, but in some instances differentiation is difficult and a correct diagnosis may be reached only by microscopic examination of the tissue. The r...

Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant. The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial ...

The classification of benign sebaceous neoplasms has been challenged both by the assertion that sebaceous adenomas are really carcinomas and by difficulties in drawing the boundaries between sebaceomas and other lesions. We performed a clinicopathologic study of 30 cases of basaloid neoplasms with sebaceous differentiation, excluding cases of definite sebaceous carcinoma with severe nuclear aty...

Sebaceous glands (SGs) undergo cyclic renewal independent of hair follicle stem cells (HFSCs) activation while HFSCs have the potential to differentiate into sebaceous gland cells, hair follicle and epidermal keratinocytes. Abnormalities of sebaceous gland progenitor cells contribute to the development of sebaceous neoplasms, but little is known about the role of HFSCs during sebaceous neoplasm...

BACKGROUND Recent studies have demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous adenomas. The aim of this study was to evaluate telomerase expression via human telomerase reverse transcriptase (hTERT) immunohistochemical staining in a spectrum of sebaceous lesions of the skin....

IMPORTANCE The molecular-genetic alterations contributing to the pathogenesis of sebaceous carcinoma and sebaceous adenoma remain poorly understood. Given that sebaceous carcinoma is associated with substantial morbidity and mortality, there is a critical need to delineate the pathways driving sebaceous carcinoma and candidate molecules for targeted therapy. OBJECTIVE To describe differential...

Calcifying epithelioma, a benign tumor derived from the hair apparatus and consisted of hair matrix cells, is relatively prevalent in females. We report a case of right preauricular calcifying epithelioma that was incidentally detected at the examination of multiple facial fractures and became an old lesion without symptoms for 40 years. The patient who was a 42-year-old male visited our depart...