نتایج جستجو برای: sdf 1a

تعداد نتایج: 34621  

2013
Tiffany J. Glass Susanta K. Hui Bruce R. Blazar Troy C. Lund

Although exceptionally high radiation dose-rates are currently attaining clinical feasibility, there have been relatively few studies reporting the biological consequences of these dose-rates in hematopoietic cell transplant (HCT). In zebrafish models of HCT, preconditioning before transplant is typically achieved through radiation alone. We report the comparison of outcomes in adult zebrafish ...

2008
Xubu Wang Caixia Li Yang Chen Yutong Hao Wen Zhou Chunhai Chen Zhengping Yu

Migration toward pathological area is the first critical step in microglia engagement during the central nervous system (CNS) injury, although the molecular mechanisms underlying microglia mobilization have not been fully understood. Here, we report that hypoxia promotes stromal cell-derived factor-1a (SDF-1a) induced microglia migration by inducing the CXC chemokine receptor 4 (CXCR4) expressi...

Journal: :Cytokine 2008
Giorgio Ghilardi Maria Luisa Biondi Olivia Turri Francesca Pateri Gianvico Melzi d'Eril Roberto Scorza

BACKGROUND AND PURPOSE Atherosclerosis is an inflammatory disease. Chemokines and chemokine receptors are known to be involved in atherogenesis. Common single nucleotide polymorphisms (SNPs) affect transcription in response to inflammatory stimuli. The aim of this study was to evaluate the correlations between MCP-1, RANTES, SDF-1, CCR2, and CCR5 gene polymorphisms with increased risk of intern...

Ali Gorji, Mohammad Amin Bayat Tork, Mohsen Saberifar, Sajad Sahab Negah,

Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide. Despite extensive investigations over the past few decades, no effective therapies exist to improve the brain function in patients with TBI. Neural tissue engineering is an attractive therapeutic approach to restore the brain structure and function of damaged tissue. Bioactive motif of Stromal cell-deri...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده علوم پزشکی 1392

زمینه و هدف: یک مسیر حیاتی که در لانه گزینی و حفظ و نگهداری سلول های بنیادی خونساز در داخل مغزاستخوان نقش دارد، اتصال sdf-1/cxcr4 است که در بدن sdf-1 یک ماده جاذب شیمیایی قوی برای سلول های cd34+cd38- مغزاستخوان از جمله سلول های بنیادی خونساز بیان کننده cxcr4، است. sdf-1 به طور وسیعی توسط اندوتلیوم مغزاستخوان انسان، سلول های رتیکولار، سلول های استئوبلاست اندوستئال و سلول های بنیادی مزانشیمی بیان...

Journal: :Stem cells and development 2012
Hilal Gul-Uludag Peng Xu Leah A Marquez-Curtis James Xing Anna Janowska-Wieczorek Jie Chen

The chemokine stromal cell-derived factor (SDF)-1α/CXCL12 and its receptor CXC chemokine receptor 4 (CXCR4) play a crucial role in the homing/engraftment and retention of hematopoietic stem/progenitor cells (HSPCs) in the bone marrow. It has been shown using the viral gene transfer technique that CXCR4 overexpression on human CD34(+) HSPC significantly improves their engraftment in murine model...

ژورنال: طب جانباز 2014

مقدمه: در طول جنگ تحمیلی عراق علیه ایران، بارها از گاز خردل (سولفور موستارد) به عنوان سلاح شیمیایی علیه ایرانیان استفاده گردید. با گذشت سال‌های طولانی از مواجهه با گاز خردل افراد مواجهه یافته هنوز از عوارض دیررس مواجهه شامل مشکلات چشمی، پوستی و ریوی رنج می برند. (SDF-1α (Stromal-Derived Factor 1α  یا CXCL12، کموکاینی است که در مطالعات متعدد، نقش مهم آن در فرآیند رهاشدن سلول های پیش‌ساز و بنیادی...

Journal: :Folia Histochemica Et Cytobiologica 2021

Introduction. Naringenin, a dihydro-flavonoid compound that shows chemotactic activity, may have good application prospect in repairing bone tissue, but its specific mechanism regeneration, especially the osteogenic differentiation of stem cells, needs for further study. The aim this study was to investigate effect naringenin on and roles C-X-C chemokine receptor type 4/stromal cell-derived fac...

1999
Jan A. Burger Meike Burger Thomas J. Kipps

Chemokines play a central role for lymphocyte trafficking and homing. The mechanisms that direct the tissue localization of B cells from patients with chronic lymphocytic leukemia (B-CLL) are unknown. We found that CLL B cells express functional CXCR4 receptors for the chemokine stromal cell-derived factor-1 (SDF-1), as demonstrated by receptor endocytosis, calcium mobilization, and actin polym...

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