Background: Activin A and follistatin belong to an anti-inflammatory auto-regulatory cycle. Patients with rheumatoid arthritis (RA) have increased activin levels in the synovial fluid tissue. During inflammation, is released systemically, then inducing its antagonist follistatin. This negative feedback active different cell types but not RA fibroblasts (SF). Fibroblasts interact endothelial cel...

background: breast cancer is the most common diagnosed cancer among women in the world. snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. traces of snail1 in metastasis of breast cancer to bone are observed. the aim of this study was to investigate the effect of specific snail1 sirnas on the prol...

PURPOSE To determine the role of Notch signaling in corneal epithelial migration and wound healing. METHODS Immunolocalization of Notch1 was performed during epithelial wound healing in vivo in mouse corneal epithelial debridement wounds and in vitro in primary human corneal epithelial cells following a linear scratch wound. The effects of Notch inhibition, using the γ-secretase inhibitor N-(...

PURPOSE In diseases such as proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy, and age-related macular degeneration, retinal pigment epithelial (RPE) cells proliferate and migrate. Moreover, platelet-derived growth factor (PDGF) has been shown to enhance proliferation and migration of RPE cells in PVR. Even resveratrol can suppress the migration and adhesion of many cell...

BACKGROUND Platelet-rich fibrin (PRF), a platelet-rich plasma (PRP) derivative mainly composed of fibrin networks, has been increasingly demonstrated to be effective in wound healing in clinical and pre-clinical animal studies. However, there has still been a concern that major growth factors may significantly be loss from PRF during its preparation through the slow clotting process. To address...

BACKGROUND Infliximab is effective in inflammatory bowel disease through several mechanisms, possibly acting at the mucosal level. AIM To assess the role of infliximab on intestinal mucosa and whether it contributes to mucosal healing. METHODS Human colonic mucosal biopsies were incubated with or without infliximab. Cultured biopsies were evaluated for histological staining, CD68, CD3, E-ca...

PURPOSE To investigate the effect and possible molecular mechanisms of fasudil on retinal microglial (RMG) cell migration. METHODS Primary cultured RMG cells were incubated with lipopolysaccharide (LPS), fasudil, and/or SB203580 (a p38 inhibitor). RMG cell motility was determined with the scratch wound assay and the Transwell migration assay. The phosphorylation of p38 and levels of matrix me...

Background and Aims: It has been suggested that thyrotropin-releasing hormone (TRH) may have functions beyond its fundamental regulating function. Previous studies demonstrated TRH promotes wound healing. We aimed to perform an in vitro study fibroblasts assess the role of wounds frequently occur diabetes. Thus, we investigated effects healing both under normoglycemic hyperglycemic-conditions....

To explore the effect of circular RNA_0025033 on proliferation, migration and invasion cervical cancer HeLa cells its molecular mechanism. The tissues adjacent 39 patients with in our hospital from January 2017 to December 2020 were selected. expression levels microRNA-1256 detected by Quantitative reverse transcription polymerase chain reaction. Cell counting kit 8 was used detect cell viabili...