Isoxazoline derivatives of the natural products eugenol, 1’- S-acetoxychavicol acetate and sclareol are prepared through 1,3-dipolar cycloaddition reactions in an aqueous buffered system. The compounds evaluated for their antitubercular antibacterial activities. Compounds 2, 2a 3f display strong activity with minimum inhibitory concentration values 26.68, 17.89 14.58 µM, respectively. Furthermo...