The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology. This mini review focuses on recent advancements in the study of signalling molecules and transduction mechanisms in S. mansoni, drawing special attention to the recently identified and characterised protein tyrosine ki...

We report seven cases of false-positive Plasmodium falciparum histidine-rich protein 2 (PfHRP2) malaria assay results in patients with acute schistosomiasis caused by Schistosoma mekongi. PfHRP2 assays were negative in travelers infected with Schistosoma mansoni or Schistosoma haematobium (n = 13). Malaria was ruled out and rheumatoid factor was negative in all patients.

TO THE EDITOR—We read the photo quiz authored by Bagdure and Khasawneh with interest [1]. The authors described a case of schistosomiasis colitis caused by Schistosoma mansoni, which was diagnosed after review of hematoxylin-eosin– stained colonic biopsy sections. This case emphasizes the challenges associated with obtaining a laboratory diagnosis of schistosomiasis based on examination of ova ...

BACKGROUND Colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support ...

BACKGROUND Schistosoma mansoni was observed and reported in Kuluva hospital Arua District in north western Uganda as early as 1902. S. mansoni is widely distributed in Uganda along permanent water bodies. OBJECTIVE To review the litreture on scistosomiasis in Uganda, since 1902. METHOD The core literature for this short review was searched from reports and publications by the British coloni...

BACKGROUND A PCR-enzyme-linked immunosorbent assay (PCR-ELISA) was developed to overcome the need for sensitive techniques for the efficient diagnosis of Schistosoma infection in endemic settings with low parasitic burden. METHODOLOGY/PRINCIPAL FINDINGS This system amplifies a 121-base pair tandem repeat DNA sequence, immobilizes the resultant 5' biotinylated product on streptavidin-coated st...

Mixed parasitic infections are common in many parts of the world. However, little is known about how concurrent infections affect the immunity to and/or pathogenesis of each other. Protection and elimination of blood-stage Plasmodium chabaudi chabaudi AS in resistant mice are characterized by a sequential activation of CD4(+) Th1 and Th2 cells. The patent egg-laying stage of the murine model of...

Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to produce adenine directly from adenosine, although the enzyme responsible for this activity was unknown. In the present work we show that S. mansoni 5´-deoxy-5´-methylthioadenosine phosphorylase (MTAP, E.C. 2.4.2.28) i...

El ratón de hierba del Brasil Akodon cursor Winge, 1887 es especialmente susceptible a la infección natural y experimental por Schistosoma mansoni Sambon, 1907. Este estudio está referido las características histopatológicas S. mansoni. Los ratones criados en laboratorio fueron infectados con 150 cercarias (cepa BH) vía subcutánea sacrificados nueve semanas más tarde. Las muestras los tejidos h...

BACKGROUND AND AIMS Oncogenes and tumor suppressor genes expression are well described in bladder cancer associated with schistosomiasis especially in Egypt. Scarce studies were directed to colorectal cancer (CRC) associated with Schistosoma mansoni (S. mansoni). Apoptosis (programmed cell death) and the genes regulating this process (e.g., Bcl-2) have recently become a focus of interest in the...