Given the time, cost and risk associated with drug development, biopharmaceutical companies typically need to have a portfolio of drugs in development to be successful. Current pressures of cost and speed to market are driving the need for more effective means of assessing the value and risks of such drug portfolios. This paper presents research to generate a prototype computer tool developed t...

Ten Do It Better, Do They? An Empirical Analysis of an Old Football Myth In this paper we investigate how the expulsion of a player influences the outcome of a football match. Common sense implies a negative impact for the affected team. However, an old football myth suggests that such an expulsion might also be beneficial since it increases the team spirit as well as the efforts of the affecte...

Scenarios have proven useful to elicit, validate and document requirements but cannot be used in isolation. Our concern in this paper is to integrate scenario-based techniques in existing methods. We propose a set of operators to support such an integration. This set is classified in two sub-sets: the one dealing with the integration of the product models of the two initial methods and the one ...

Nowadays standard technologies play important roles in enhancing sharability, reusability and interoperability of learning contents. However, there is a lack of pedagogical justification of the contents implemented with the standards. This paper discusses the standard-compliance of our ontology-based modeling framework and how the framework gives theoretical justification to standardcompliant l...

due to the nature of the sediment data, selection of appropriate methods for processing the data before entering them to the artificial intelligence models can enhance the reliability of simulations results. in this study, the effects of sediment data processing procedures on ann and anfis models outputs in 7 dez basin stations were evaluated. accordingly, three scenarios were considered: in th...

(1) Laboratory for Hydrogeology, Department of Geology-Geography, Faculty of Exact Science, Catholic University of Leuven, Redingenstraat 16, 3000 Leuven, Belgium (2) Department of Hydrogeology and Engineering Geology, University of Miskolc, Miskolc, Hungary (3) Hydrogeology and Environmental Geology, Department of Georesources, Geotechnologies and Building Materials (GEOMAC), University of Liè...

Background: Extraterrestrial Encounter To date, humanity has not made any form of contact with extraterrestrial intelligence (ETI). But we cannot rule out the possibility that one or more ETI exist in our galaxy, or that we could detect, communicate with, or in other ways have contact with them in the future. There have been many analyses of how contact would proceed, but these tend to focus na...

Illicit drug use creates significant burden at societal, family and personal levels. Every year substantial resources are allocated for treatment and the consequences of illicit drug use in Australia and around the world. Heroin is one of the major forms of illicit drugs. Several independent heroin treatment strategies or interventions exist and state-of-the art research demonstrates their effi...

Worldwide food security and water safety issues necessitate countries with low water use efficiency of crop production (CWUE) to increase it and reduce regional CWUE variations. CWUE function was estimated with stochastic frontier analysis, and CWUE variation was decomposed on inter-continental, intra-continental and international level with variance decomposition method. It is proposed that in...