The Mid-Pliocene (ca 3Myr ago) was a relatively warm period, with increased atmospheric CO2 relative to pre-industrial. It has therefore been highlighted as a possible palaeo-analogue for the future. However, changed vegetation patterns, orography and smaller ice sheets also influenced the Mid-Pliocene climate. Here, using a general circulation model and ice-sheet model, we determine the relati...

In this study, the authors examine exhaustive business data on Japanese firms, which cover nearly all companies in the midand large-scale ranges in terms of firm size, to reach several key findings on profits/sales distribution and business growth trends. First, detailed balance is observed not only in profits data but also in sales data. Furthermore, the growth-rate distribution of sales has w...

BACKGROUND The SF-6D is a new single summary preference-based measure of health derived from the SF-36. Empirical work is required to determine what is the smallest change in SF-6D scores that can be regarded as important and meaningful for health professionals, patients and other stakeholders. OBJECTIVES To use anchor-based methods to determine the minimally important difference (MID) for th...

Absorption spectra of aqueous solution of ''chaotropes'' (structure maker) and ''kosmotropes'' (structure breaker) have been recorded in the mid-infrared (MIR) and terahertz (THz) spectral region. A different impact of the two groups of solutes on the absorption spectrum of water was found in the recorded THz spectra. A concentration-dependent increased absorption across the investigated THz sp...

In this article we discuss the ancestry of sequences sampled from the coalescent with recombination with constant population size 2N. We have studied a number of variables based on simulations of sample histories, and some analytical results are derived. Consider the leftmost nucleotide in the sequences. We show that the number of nucleotides sharing a most recent common ancestor (MRCA) with th...

Influenza C contributes to economic damage caused by working days lost through absence or inefficiency and may occasionally cause an acute respiratory illness in a paediatric setting. All Influenza C sequences from the NCBI Influenza Virus Resource were examined to determine the date of the most recent common ancestor (t-MRCA), the average nucleotide substitution rate, and the location of resid...

Earth's tectonic plates are generally considered to be driven largely by negative buoyancy associated with subduction of oceanic lithosphere. In this context, mid-ocean ridges (MORs) are passive plate boundaries whose divergence accommodates flow driven by subduction of oceanic slabs at trenches. We show that over the past 80 million years (My), the East Pacific Rise (EPR), Earth's dominant MOR...