Diazonium chlorides of 5-amino-3-methypyrazole 1a and 5-amino-4-phenylpyrazole 1b coupled with 1,3-indanedione 2 and led to the formation of acyclic hydrazone 3a and a cyclic product indenopyrazolotriazine 4b respectively. Cyclization of the hydrazone 3a by boiling in acetic acid afforded the corresponding 4a. The hydrazone 3a reacted with malononitrile in boiling ethanol in the presence of pip...

The title compound, C(11)H(11)N(3)O(2)·H(2)O, was obtained by the reaction of 2-acetyl-phenol with cyano-acetohydrazide in methanol. The asymmetric unit contains two hydrazone mol-ecules and two water mol-ecules of crystallization. There is an intra-molecular O-H⋯N hydrogen bond in each hydrazone mol-ecule. The crystal structure is stabilized by inter-molecular N-H⋯O, O-H⋯O and O-H⋯N hydrogen b...

In the title compound, C(17)H(19)N(3)O·CH(3)OH, the hydrazone mol-ecule exists in a trans geometry with respect to the methyl-idene unit and the dihedral angle between the two substituted benzene rings is 42.6 (2)°. In the crystal, the components are linked through N-H⋯O and O-H⋯O hydrogen bonds, forming [100] chains of alternating hydrazone and methanol mol-ecules.

Rapid and catalyst-free hydrazone ligation reaction between ortho-halobenzaldehyde derivatives and peptide/protein hydrazides was observed at neutral pH and room temperature. 2-Chlorobenzaldehyde exhibited the fastest reaction and highest conversion rates among the series of ortho-halobenzaldehydes. The resulting hydrazone-containing bioconjugation products were also found to be fairly stable u...

In the title compound, C(15)H(12)Cl(2)N(2)O(2)·CH(3)OH, the hydrazone mol-ecule displays an E configuration about the C=N bond. The dihedral angle between the two benzene rings is 4.6 (2)°. In the crystal structure, the hydrazone and methanol mol-ecules are linked into a chain propagating along the a axis via N-H⋯O and O-H⋯O hydrogen bonds.

Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. The development of novel hydrazones containing compounds possess a wide verities of biological activities like as antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer, antimicrobial, anti-tuberculosis, and antifungal activity. Hydrazones posses...

Sorbent materials based on a hydrazone Schiff base compound, C(14)H(11)BrN(4)O(4), were prepared either by immobilizing the ligand into sol-gel (SG1) or bonding to silica (SG2). The sorbent materials were characterized by FT-IR, EDX, SEM, TEM, and TGA. The sorption characteristics of a matrix of eight transition metal ions (Ag(+), Cu(2+), Co(2+), Ni(2+), Fe(3+), Pb(2+), Zn(2+), and Mn(2+)) usin...

N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone (BBNH) inhibits both the DNA polymerase and ribonuclease H (RNase H) activities of the human immunodeficiency virus type 1 reverse transcriptase. In this study, we show that BBNH binding impacts on the stability of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) heterodimer. The Gibbs free energy of dimer di...

The title compound, [Ru(C10H8N2)2(C16H12N4O)](BF4)2·3CH2Cl2, crystallizes with one complex dication, two BF4 (-) counter-anions and three di-chloro-methane solvent mol-ecules in the asymmetric unit. The central Ru(II) atom adopts a distorted octa-hedral coordination sphere with two 2,2'-bi-pyridine (bpy) and one quinoline-2-carbaldehyde (pyridine-2-carbon-yl)hydrazone (HL) ligand. The hydrazone...

Introduction Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus (VRE) have accomplished important rates of colonization and infection in most intensive care units. These multidrug-resistant strains of MRSA and VRE have been causing serious problems in health care. The rising clinical importance of drug-resistant pathogens has lent necessity to drug developm...