mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. several recombinant protein systems have been introduced to the market, most of which are under clinical development. in spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

Mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. Several recombinant protein systems have been introduced to the market, most of which are under clinical development. In spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

Offshore probabilistic tsunami hazard assessments (PTHAs) are increasingly available for earthquake generated tsunamis. They provide standardized representations of scenarios, their uncertain occurrence-rates, and models the deep ocean waveforms. To quantify onshore hazards it is natural to combine this information with a site-specific inundation model, but computationally challenging do accura...

The U.S. Nuclear Regulatory Commission (NRC) promulgated its regulations on the “Radiological Criteria for License Termination” in 10 CFR Part 20, Subpart E. The regulations require that, for the release of sites for unrestricted use, the total effective dose equivalent (TEDE) to an average member of a critical group, resulting from residual radioactivity that is distinguishable from background...

Uncertainty quantification is a critical missing component in radio interferometric imaging that will only become increasingly important as the big-data era of radio interferometry emerges. Statistical sampling approaches to perform Bayesian inference, like Markov Chain Monte Carlo (MCMC) sampling, can in principle recover the full posterior distribution of the image, from which uncertainties c...

The reliability of and confidence in predictions from model simulations are crucial—these predictions can significantly affect risk assessment decisions. For example, the fate of contaminants at the U.S. Department of Energy’s Hanford Site has critical impacts on long-term waste management strategies. In the uncertainty estimation efforts for the Hanford Site-Wide Groundwater Modeling program, ...