S-adenosyl methionine (SAM) is a ubiquitous methyl donor that was reported to have chemo- protective activity against liver cancer, however the molecular footprint of SAM is unknown. We show here that SAM selectively inhibits growth, transformation and invasiveness of hepatocellular carcinoma cell lines but not normal primary liver cells. Analysis of the transcriptome of SAM treated and untreat...

S-adenosylmethionine (SAM) minimizes alcohol hepatotoxicity; however, the molecular mechanisms responsible for SAM hepatoprotection remain unknown. Herein, we use proteomics to determine whether the hepatoprotective action of SAM against early-stage alcoholic liver disease is linked to alterations in the mitochondrial proteome. For this, male rats were fed control or ethanol-containing liquid d...

Analogy-based Story Generation (ASG) is a relatively under-explored approach for story generation and computational narrative. In this paper, we present the SAM (Story Analogies through Mapping) algorithm as our attempt to expand the scope and complexity of stories generated by ASG. Comparing with existing work and our prior work, there are two main contributions of SAM: it employs 1) analogica...

Pascal’s mechanical calculator and Babbage’s Analytic Engine set the stage for a great deal of modern computing machinery. Modern versions of these concepts were finally realized in von Neumann’s architecture in about 1950. However, the science of computing does not depend on physical implementations of these ideas, but rather on virtual machines—that is, abstractions that perform computations ...

Pfalzer AC, Choi SW, Tammen SA, Park LK, Bottiglieri T, Parnell LD, Lamon-Fava S. S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages. Physiol Genomics 46: 617–623, 2014. First published July 15, 2014; doi:10.1152/physiolgenomics.00056.2014.—S-adenosylmethionine (SAM), the unique methyl donor in DNA methylation, has been shown to...

Smoothing approaches to the Simultaneous Localization and Mapping (SLAM) problem in robotics are superior to the more common filtering approaches in being exact, better equipped to deal with non-linearities, and computing the entire robot trajectory. However, while filtering algorithms that perform map updates in constant time exist, no analogous smoothing method is available. We aim to rectify...

The suppressive effects on acute alcoholic liver injury of S-adenosylmethionine (SAM) and the sake yeast, Saccharomyces cerevisiae Kyokai No. 9, have been shown previously. To enhance the suppression of acute alcoholic liver injury by sake yeast, we prepared SAM-accumulating sake yeast (SAM yeast). Male C57BL/6 mice that had been fed on a diet containing 0.25% SAM yeast or sake yeast for two we...

Ethylene, a gaseous hormone in plants, is involved in the regulation of a wide range of plant physiological processes, including leaf abscission, fruit ripening, and flower senescence (Yang and Hoffman, 1984). SAM or Adomet synthetase (ATP:L-methionine S-adenosyltransferase; EC 2.5.1.6) catalyzes the conversion of Met to SAM in the presence of ATP and Mg2+, which is the first step in ethylene b...

The present study is to indicate that the comparison between sectoral production multipliers of an input-output (I/O) model and a social accounting matrix (SAM) framework is almost impossible without taking into account accounting balances and theoretical considerations. Theoretically, the I/O model provides the Leontief’s production function, on the basis of which sectoral output multiplier ca...