Macrophages are considered to be the mediators of resistance to extra-intestinal Salmonella infections. Nevertheless, the initial cellular response to Salmonella infections consists primarily of polymorphonuclear leukocytes (PMN). To determine whether PMN serve an important function for the infected host, we made mice neutropenic with the rat mAb to RB6-8C5 and infected them i.v. with approxima...

Nicotinic acid is required by most isolates of Salmonella enterica (serovar Dublin), a pathogen of cattle. A single nadA missense mutation causes the nutritional requirement of all serovar Dublin isolates tested. Models for persistence of this allele are tested and discussed.

The induction by intracellular pathogens of interleukin-12 (IL-12) secretion is of particular importance since this cytokine has been shown to be necessary for optimal cell-mediated immune responses. Several recent investigations have suggested that cultured macrophages are a significant source of IL-12 following intracellular infection with pathogens such as Salmonella spp. In an effort to cri...

In 1926 Pesch reported a case of meningitis due to a Gaertner-like organism. The culture was examined by Bruce White (1926) and was found by him to be identical with an organism sent to him by Dr. J. W. Bigger. This Dublin strain was isolated from a case of fatal fever supervening after a kidney operation. Bruce White (1929) has exhaustively examined the serology of the Dublin strain. He has sh...

Cross-protection induced by primary infection with Abortusovis and Gallinarum was examined against challenge injection with these Salmonella serotypes as well as with Dublin and Choleraesuis, the other virulent serotypes. Abortusovis induced efficient protection against the other Salmonella. Gallinarum was ineffective against Choleraesuis. Even with low multiplication in mice, the Gallinarum J9...

ProP is required for the survival of desiccated Salmonella Typhimurium on a 2 stainless steel surface. 3 4 Sarah Finn, Kristian Händler, Orla Condell, Aoife Colgan, Shane Cooney, P. 5 McClure, A. Amézquita, Jay C. D. Hinton, and Séamus Fanning 6 7 UCD Centre for Food Safety, School of Public Health, Physiotherapy & Population 8 Science, University College Dublin, Belfield, Dublin 4 and Moyne In...

This is the first reported case of liver abscess attributable to Salmonella serovar Dublin infection and also the fourth case of Salmonella liver abscess complicated with hepatocellular carcinoma reported since 1990. Drainage combined with intravenous antibiotics resulted in improvement, but recovery regressed again. Subsequent hepatic left lobectomy led to full recovery.