Histone acetyltransferases have been shown to participate in many essential cellular processes, particularly those associated with activation of transcription. SAGA (Spt-Ada-Gcn5 acetyltransferase) and SLIK (SAGA-like) are two highly homologous multisubunit histone acetyltransferase complexes that were originally identified in the yeast Saccharomyces cerevisiae. Here, we identify the protein Sg...

The SAGA complex of Saccharomyces cerevisiae is required for the transcription of many RNA polymerase II-dependent genes. Previous studies have demonstrated that SAGA possesses histone acetyltransferase activity, catalyzed by the SAGA component Gcn5. However, the transcription of many genes, although SAGA dependent, is Gcn5 independent, suggesting the existence of distinct SAGA activities. We h...

Histone modifications are a crucial source of epigenetic control. SAGA (Spt-Ada-Gcn5 acetyltransferase) is a chromatin-modifying complex that contains two distinct enzymatic activities, Gcn5 and Ubp8, through which it acetylates and deubiquitinates histone residues, respectively, thereby enforcing a pattern of modifications that is decisive in regulating gene expression. Here, I discuss the lat...

Summary The study presents a comparative analysis of eight Vegetation Indices (VIs) used to examine vegetation greenness over the northern coasts Iceland. geographical extent area is set by coordinates two fjords, Eyjafjörður and Skagafjörður, notable for their agricultural significance. in Iceland fragile due harsh climate, climate change, overgrazing volcanic activity, which increase soil ero...

Survivin is an antiapoptotic protein highly expressed in malignant cells that confers resistance to cytotoxic therapy. Granzyme B is a potent cytotoxic protein that is released from mammalian natural killer cells and CTLs following noxious stimuli, including foreign invaders. Here, we took advantage of the properties of these two functionally divergent molecules to create a molecular agent that...

Mari Yoshihara1, Yasushi Kubota1,2, Makoto Fukuda3, Tomoya Kishi3, Yuji Ikeda3, Shinya Kimura1 1Saga University Faculty of Medicine, Department of Internal Medicine, Division of Hematology Respiratory Medicine, and Oncology, Saga, Japan 2Saga University Faculty of Medicine Hospital, Department of Transfusion Medicine, Saga, Japan 3Saga University Faculty of Medicine, Department of Internal Medi...

Yosuke Yamada, Stéphane Blanc, Yuichiro Nishida, Kazutoshi Nishijima, Naoyuki Ebine, Timothy Shriver, and Dale A. Schoeller Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin; Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan; Université de Strasbourg, Institut Pluridisciplinaire Hubert Curien, Département d’Ecologie, Physiologie et Ethologie, Cent...

This report documents the latest work in the SAGA (Spray Advisor using Genetic Algorithms) project, the goal of which is to provide an effective means for a computer to recommend an optimal set of parameters for spraying a wooded area with pesticide. Current work is in two directions. One of these is the maintenance of older SAGA programs, some of which were built on now-obsolete platforms. The...

SAGA, a recently described protein complex in Saccharomyces cerevisiae, is important for transcription in vivo and possesses histone acetylation function. Here we report both biochemical and genetic analyses of members of three classes of transcription regulatory factors contained within the SAGA complex. We demonstrate a correlation between the phenotypic severity of SAGA mutants and SAGA stru...

The yeast SAGA (Spt-Ada-Gcn5-acetyltransferase) coactivator complex exerts functions in gene expression, including activator interaction, histone acetylation, histone deubiquitination, mRNA export, chromatin recognition, and regulation of the basal transcription machinery. These diverse functions involve distinct modules within this multiprotein complex. It has now become clear that yeast SAGA ...